Association of Increased Amygdala Activity with Stress-Induced Anxiety but not Social Avoidance Behavior in Mice
Association of Increased Amygdala Activity with Stress-Induced Anxiety but not Social Avoidance Behavior in Mice
复制标题
小鼠杏仁核活动增加与应激性焦虑而非社交回避行为的关联
DOI：
10.1007/s12264-021-00762-0
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发表时间：
2021-09-07
影响因子：
5.6
通讯作者：
Zhang, Wen-Hua
中科院分区：
文献类型：
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作者：
Huang, Shou-He;Liu, Wei-Zhu;Zhang, Wen-Hua
慢性压力导致许多精神障碍，包括社交和焦虑障碍，这些障碍与基底外侧杏仁核（BLA）神经元的过度激活有关。然而，并非所有人都会患上精神疾病，许多人对压力暴露表现出相当大的弹性。BLA神经元活动是否参与调节个体对压力的脆弱性仍然是难以捉摸的。在这项研究中，使用慢性社会失败压力（CSDS）的小鼠模型，我们根据它们的社会交往行为将小鼠分为易感和弹性亚组。使用体内纤维光度法和体外膜片钳记录，我们发现，CSDS持续（从应激中恢复20天后）增加BLA神经元的活动，在所有的小鼠，无论其敏感或弹性的性质，虽然受损的社会互动行为只观察到在易感小鼠。另一方面，焦虑样行为的增加在两组中都很明显。值得注意的是，CSDS诱导的BLA神经元活性的增加与小鼠中焦虑样行为的增加而不是社交回避行为密切相关。这些发现为我们理解杏仁核神经元活动在介导应激相关精神障碍中的作用提供了新的见解。
Chronic stress leads to many psychiatric disorders, including social and anxiety disorders that are associated with over-activation of neurons in the basolateral amygdala (BLA). However, not all individuals develop psychiatric diseases, many showing considerable resilience against stress exposure. Whether BLA neuronal activity is involved in regulating an individual's vulnerability to stress remains elusive. In this study, using a mouse model of chronic social defeat stress (CSDS), we divided the mice into susceptible and resilient subgroups based on their social interaction behavior. Using in vivo fiber photometry and in vitro patch-clamp recording, we showed that CSDS persistently (after 20 days of recovery from stress) increased BLA neuronal activity in all the mice regardless of their susceptible or resilient nature, although impaired social interaction behavior was only observed in susceptible mice. Increased anxiety-like behavior, on the other hand, was evident in both groups. Notably, the CSDS-induced increase of BLA neuronal activity correlated well with the heightened anxiety-like but not the social avoidance behavior in mice. These findings provide new insight to our understanding of the role of neuronal activity in the amygdala in mediating stress-related psychiatric disorders.