Highly Enantioselective [2+2+2] Cycloaddition of Enediynes Enabled by Cobalt/Organophotoredox Cooperative Catalysis
Highly Enantioselective [2+2+2] Cycloaddition of Enediynes Enabled by Cobalt/Organophotoredox Cooperative Catalysis
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DOI：
10.1021/acscatal.1c02410
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发表时间：
2021-07-15
期刊：
影响因子：
12.9
通讯作者：
Yamamoto，Yoshihiko
中科院分区：
文献类型：
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作者：
Yasui，Takeshi;Tatsumi，Rine;Yamamoto，Yoshihiko
在这里，我们报道了钴和光氧化还原双重催化使烯二炔类化合物的[2+2+2]环加成反应生成含有四元桥头碳的三环环己二烯。使用了多种烯二炔，并以良好到高的产率获得了相应的环己二烯。使用手性配体(S)-Segphos，实现了高度不对称反应，从而获得了高度富含对映体的环己二烯。
Herein, we report dual cobalt and photoredox catalysis enabled [2+2+2] cycloaddition of enediynes to produce tricyclic cyclohexadienes bearing a quaternary bridgehead carbon. A variety of enediynes were used, and the corresponding cyclohexadienes were obtained in good to high yields. The use of a chiral ligand, (S)-Segphos, enabled a highly enantioselective reaction allowing access to highly enantio-enriched cyclohexadienes.