Cytomegalovirus infection in immunocompetent patients
Cytomegalovirus infection in immunocompetent patients
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DOI：
10.1086/379711
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发表时间：
2003-12-15
影响因子：
11.8
通讯作者：
Rice, P
中科院分区：
文献类型：
--
作者：
Wreghitt, TG;Teare, EL;Rice, P
免疫功能正常患者巨细胞病毒（CMV）感染的相关症状尚未得到很好的记录。从1998年12月到2001年6月，从英国剑桥和切姆斯福德的7630名患者的血清样本中检测巨细胞病毒免疫球蛋白m。巨细胞病毒免疫球蛋白G抗体被用来确认巨细胞病毒感染。共发现124例巨细胞病毒感染患者（全科医生治疗106例，住院18例）。最常见的症状是不适（67%）、发热（46%）和出汗（46%），最常见的发现是肝功能检查结果异常（69%）。12%的患者病情复发，许多患者的症状持续长达32周（平均症状持续时间为7.8周）。全科医生报告说，在诊断巨细胞病毒感染方面有显著的好处；它提供了保证，并避免了进一步调查的需要。我们已经在全科医生或住院的免疫功能正常的患者中确定了与巨细胞病毒感染相关的症状。
Symptoms associated with cytomegalovirus ( CMV) infection in immunocompetent patients are not well documented. From December 1998 through June 2001, serum samples obtained from 7630 patients in Cambridge and Chelmsford, United Kingdom, were tested for CMV immunoglobulin M. CMV immunoglobulin G avidity was used to confirm CMV infection. A total of 124 patients ( 106 patients treated by general practitioners [ GPs] and 18 hospitalized patients) with CMV infection were identified. The most frequent symptoms were malaise ( 67%), fever ( 46%), and sweats ( 46%), and the most frequent finding was abnormal liver function test results ( 69%). Twelve percent of patients had a relapsing illness, and many had symptoms that lasted for up to 32 weeks ( mean duration of symptoms, 7.8 weeks). GPs reported that there was a significant benefit in making the diagnosis of CMV infection; it provided reassurance and avoided the need for further investigations. We have identified symptoms associated with CMV infection in immunocompetent patients who present to GPs or who are admitted to the hospital.