Protection of oral hydrogen water as an antioxidant on pulmonary hypertension.
Protection of oral hydrogen water as an antioxidant on pulmonary hypertension.
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DOI：
10.1007/s11033-013-2653-9
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发表时间：
2013-09
影响因子：
2.8
通讯作者：
Wang Z
中科院分区：
文献类型：
--
作者：
He B;Zhang Y;Kang B;Xiao J;Xie B;Wang Z
本研究旨在探讨氢作为一种抗氧化剂对野百合碱（MCT）诱导的肺动脉高压（PH）的保护作用。将48只SD大鼠随机分为4组：假手术组、MCT组、MCT+Oral-H2组和MCT+Inj-H2组。结果显示，MCT组平均肺动脉压、右心室重量和右心室肥厚指数均显著高于SHAM组;肺组织炎症反应、心钠素、3-硝基酪氨酸和细胞间黏附分子-1也显著增加。这些指标在MCT+Oral-H2组和MCT+Inj-H2组均显著降低，表明Oral-H2和Inj-H2具有类似的预防PH发展和减轻RV肥大的作用。氢的保护作用与其抗氧化能力和减轻肺部炎症反应的作用有关。虽然Oral-H2比Inj-H2更方便，但Oral-H2可能是未来临床使用的理想选择。
This study aimed to explore the protective effect of hydrogen as an antioxidant on monocrotaline (MCT)-induced pulmonary hypertension (PH). Forty-eight SD rats were equally randomized into four groups: SHAM group, MCT group, MCT+Oral-H2 group and MCT+Inj-H2 group. The results showed that the mean pulmonary arterial pressure, right ventricle weight and right ventricular hypertrophy index in MCT group were significant higher than those in SHAM group; pulmonary inflammatory response, atrial natriuretic factor, 3-nitrityrosine and intercellular adhesion molecule-1 were also increased significantly in MCT group. These indexes were decreased significantly in both MCT+Oral-H2 group and MCT+Inj-H2 group, which indicate Oral-H2 and Inj-H2 have similar effects of preventing the development of PH and mitigating RV hypertrophy. The protective effect of hydrogen is associated with its antioxidative ability and action of reducing pulmonary inflammatory response. While Oral-H2 is more convenient than Inj-H2, Oral-H2 may be ideal for clinical use in future.
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影响因子：
10.8
作者：
Redout, Everaldo M.;Wagner, Marijke J.;Simonides, Warner S.
通讯作者：
Simonides, Warner S.
DOI：
10.1111/j.1365-2362.2006.01681.x
发表时间：
2006-09-01
影响因子：
5.5
作者：
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通讯作者：
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4
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
24
作者：
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通讯作者：
Chung, Wendy K.