MMP1, 2, 3, 7, and 9 Gene Polymorphisms and Urinary Cancer Risk: A Meta-Analysis
MMP1, 2, 3, 7, and 9 Gene Polymorphisms and Urinary Cancer Risk: A Meta-Analysis
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DOI：
10.1089/gtmb.2015.0123
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发表时间：
2015-10-01
影响因子：
1.4
通讯作者：
Kong Chuize
中科院分区：
文献类型：
--
作者：
Liu Tao;Zuo Li;Kong Chuize
背景：基质金属蛋白酶（matrix metalloproteinases, MMPs）是一类高度保守的金属依赖性蛋白水解酶，在肿瘤侵袭和转移过程中发挥重要作用。关于MMP1、MMP2、MMP3、MMP7和MMP9基因多态性与尿路癌风险之间的关系，已经开展了许多研究。然而，这些已发表研究的数据是相互矛盾的，具有较低的统计效力。方法：在本研究中，我们对PubMed和万方数据库中截至2015年5月发表的12篇不同出版物进行了荟萃分析，以更好地评估所谓的关联。确定比值比（OR）和95%置信区间（CI）以显示关联强度。结果：发现了一些显著的相关性。对于MMP1 -1607 1G/2G多态性，发现2G等位基因与膀胱癌（2G2G+2G1G vs. 1G1G: OR=0.57, 95% CI=0.36-0.93, p（异质性）=0.001）和肾癌（2G1G vs. 1G1G: OR=0.57, 95% CI=0.39-0.82, p（异质性）=0.567）呈负相关。对于MMP2 -1306 C/T多态性，与亚洲人群膀胱癌的T等位基因呈负相关（TT+TC vs. CC: OR=0.41, 95% CI=0.18-0.94, p（异质性）=0.195）。对于MMP7 -181A/G多态性，发现膀胱癌风险降低（G等位基因vs. a等位基因：OR=0.81, 95% CI=0.66-0.98, p（异质性）=0.325）。结论：总之，我们的研究表明，所有人群中MMP1的遗传多态性，但仅在亚洲人群中，MMP2和MMP7的遗传多态性可能保护膀胱癌的风险。未来有必要进行更大样本量的研究，以进一步更详细地评估这些关联。
Background: The matrix metalloproteinases (MMPs) are a family of highly conserved, metal-dependent proteolytic enzymes that play an important role in tumor invasion and metastasis. Many studies have been carried out on the association between polymorphisms in the MMP1, MMP2, MMP3, MMP7, and MMP9 genes and urinary cancer risk. However, the data from these published studies are conflicting and have low statistical power. Methods: In this study, we performed a meta-analysis of 12 different publications from the PubMed and WanFang databases, published up to May 2015, to better assess the purported associations. Odds ratios (OR) and 95% confidence intervals (CI) were determined to reveal association strengths. Results: Some significant associations were found. For the MMP1 -1607 1G/2G polymorphism, a negative association was identified for the 2G allele in bladder cancer (2G2G+2G1G vs. 1G1G: OR=0.57, 95% CI=0.36-0.93, p(heterogeneity)=0.001) and renal cell carcinoma (2G1G vs. 1G1G: OR=0.57, 95% CI=0.39-0.82, p(heterogeneity)=0.567). For the MMP2 -1306 C/T polymorphism, there was a negative association with the T allele for bladder cancer in the Asian population (TT+TC vs. CC: OR=0.41, 95% CI=0.18-0.94, p(heterogeneity)=0.195). For the MMP7 -181A/G polymorphism, a decreased bladder cancer risk was found (G-allele vs. A-allele: OR=0.81, 95% CI=0.66-0.98, p(heterogeneity)=0.325). Conclusion: In summary, our study showed evidence that genetic polymorphisms in MMP1 for all populations, but only in the Asian population for MMP2 and MMP7, may protect against bladder cancer risk. Future studies with larger sample sizes are warranted to further evaluate these associations in more detail.