Proton MRS of the unilateral substantia nigra in the human brain at 4 tesla:: Detection of high GABA concentrations
Proton MRS of the unilateral substantia nigra in the human brain at 4 tesla:: Detection of high GABA concentrations
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DOI：
10.1002/mrm.20761
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发表时间：
2006-02-01
影响因子：
3.3
通讯作者：
Gruetter, R
中科院分区：
文献类型：
--
作者：
Öz, G;Terpstra, M;Gruetter, R
帕金森病（PD）的特征是黑质（SN）中多巴胺能神经元的丢失，其原因尚不清楚。早期SN病理学的特征可以证明有利于PD的治疗和诊断。本研究表明，使用短回波（5 ms）刺激回波采集模式（STEAM）光谱和LCModel，可以在4特斯拉下从单侧SN测量由10种代谢物组成的神经化学谱，包括γ-氨基丁酸（GABA），谷氨酸（Glu）和谷胱甘肽（GSH）。SN的神经化学特征是独特的，其特征在于与皮质相比GABA/Glu比率高四倍，与已建立的神经化学非常一致。使用编辑验证了SN中GABA水平升高的存在，表明部分体积效应大大降低。这些研究结果建立了通过小体积的单体素光谱法获得单侧人类SN的神经化学特征的可行性。
Parkinson's disease (PD) is characterized by loss of dopaminergic neurons in the substantia nigra (SN), the cause of which is unknown. Characterization of early SN pathology could prove beneficial in the treatment and diagnosis of PD. The present study shows that with the use of short-echo (5 ms) Stimulated-Echo Acquisition Mode (STEAM) spectroscopy and LCModel, a neurochemical profile consisting of 10 metabolites, including gamma-aminobutyric acid (GABA), glutamate (Glu), and glutathione (GSH), can be measured from the unilateral SN at 4 tesla. The neurochemical profile of the SN is unique and characterized by a fourfold higher GABA/Glu ratio compared to the cortex, in excellent agreement with established neurochemistry. The presence of elevated GABA levels in SN was validated with the use of editing, suggesting that partial volume effects were greatly reduced. These findings establish the feasibility of obtaining a neurochemical profile of the unilateral human SN by single-voxel spectroscopy in small volumes.