A STEREOTAXIC METHOD FOR SMALL ANIMALS USING EXPERIMENTALLY DETERMINED REFERENCE PROFILES
A STEREOTAXIC METHOD FOR SMALL ANIMALS USING EXPERIMENTALLY DETERMINED REFERENCE PROFILES
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DOI：
10.1016/0165-0270(86)90022-1
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发表时间：
1986-12-01
影响因子：
3
通讯作者：
BETZ, M
中科院分区：
文献类型：
--
作者：
SCHULLER, G;RADTKESCHULLER, S;BETZ, M
在蝙蝠中，传统的立体定位方法不能产生足够的位置精度，以允许可靠的记录和在听觉系统的亚核中注射示踪剂。在一个新开发的立体定位系统中，实验测量的颅骨轮廓线图案被用来确定动物的大脑位置，其精度为±。100微米通过将神经生理学立体定位程序与大脑神经解剖学处理的标准化相结合，记录、刺激或注射的位置可以容易地转换成大脑图谱坐标。这有助于动物内部和动物之间数据的汇编和比较。该系统并不限于在蝙蝠中使用，并且可以很容易地适用于其他实验动物。
In bats conventional stereotaxic methods do not yield sufficient positional accuracy to allow reliable recordings and tracer injections in subnuclei of the auditory system. In a newly developed stereotaxic system experimentally measured patterns of skull profile lines are used to define the animal''s brain position with an accuracy of .+-. 100 .mu.m. By combining the neurophysiological stereotaxic procedure with a standardization of the neuroanatomical processing of the brains, the location of recordings, stimulations or injections can be readily transformed into brain atlas coordinates. This facilitates the compilation and comparison of data within and among animals. The system is not restricted to use in bats and can be readily adapted to other experimental animals.