The generation of adjunctive behavior under conditions of drug self‐administration
The generation of adjunctive behavior under conditions of drug self‐administration
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自我给药条件下辅助行为的产生
DOI：
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发表时间：
1989
影响因子：
1.6
通讯作者：
C. Johanson
中科院分区：
文献类型：
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作者：
K. Grant;C. Johanson
研究了恒河猴在固定间隔(FI)食物颗粒注射或静脉注射可卡因或咪达唑仑(IV)条件下附加行为的产生。FI程序值为1.5~120min。在第二个同时可用的杠杆上的每一次反应都会导致注入生理盐水。接受生理盐水输注的次数是强化剂(食物或药物)输送间隔的双调函数(倒U)。这种双音调功能是附加行为的特征，并强烈地表明，导致注入生理盐水的反应是一种附加行为。此外，这些结果表明，间歇性给药计划可以产生附属行为。自我给药剂量的增加使生理盐水输注的Bitonic功能右移。附加行为功能的这种转变与附加行为的产生依赖于增强剂的大小和间歇性递送的假设是一致的。
The generation of adjunctive behavior was studied in rhesus monkeys responding under fixed-interval (FI) schedules of food pellet delivery or intravenous (iv) infusions of cocaine or midazolam. The FI schedule value ranged from 1.5 to 120 min. Each response on a second, concurrently available lever resulted in an infusion of saline. The number of saline infusions received was a bitonic function (inverted U) of the interval of reinforcer (food or drug) delivery. This bitonic function is characteristic of adjunctive behavior and strongly suggests that the responding that results in the infusion of saline was an adjunctive behavior. Furthermore, these results establish that intermittent schedules of drug delivery can generate adjunctive behavior. Increases in the dose of drug self-administered shifted the bitonic function of saline infusions to the right. This shift in the function of adjunctive behavior is consistent with the hypothesis that the generation of adjunctive behavior is dependent upon both the magnitude and the intermittent delivery of the reinforcer.