Resveratrol Ameliorates the Depressive-Like Behaviors and Metabolic Abnormalities Induced by Chronic Corticosterone Injection.
Resveratrol Ameliorates the Depressive-Like Behaviors and Metabolic Abnormalities Induced by Chronic Corticosterone Injection.
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白藜芦醇可改善慢性皮质酮注射引起的抑郁样行为和代谢异常
DOI：
10.3390/molecules21101341
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发表时间：
2016-10-13
期刊：
影响因子：
--
通讯作者：
Fang XY
中科院分区：
文献类型：
--
作者：
Li YC;Liu YM;Shen JD;Chen JJ;Pei YY;Fang XY
Chronic glucocorticoid exposure is known to cause depression and metabolic disorders. It is critical to improve abnormal metabolic status as well as depressive-like behaviors in patients with long-term glucocorticoid therapy. This study aimed to investigate the effects of resveratrol on the depressive-like behaviors and metabolic abnormalities induced by chronic corticosterone injection. Male ICR mice were administrated corticosterone (40 mg/kg) by subcutaneous injection for three weeks. Resveratrol (50 and 100 mg/kg), fluoxetine (20 mg/kg) and pioglitazone (10 mg/kg) were given by oral gavage 30 min prior to corticosterone administration. The behavioral tests showed that resveratrol significantly reversed the depressive-like behaviors induced by corticosterone, including the reduced sucrose preference and increased immobility time in the forced swimming test. Moreover, resveratrol also increased the secretion of insulin, reduced serum level of glucose and improved blood lipid profiles in corticosterone-treated mice without affecting normal mice. However, fluoxetine only reverse depressive-like behaviors, and pioglitazone only prevent the dyslipidemia induced by corticosterone. Furthermore, resveratrol and pioglitazone decreased serum level of glucagon and corticosterone. The present results indicated that resveratrol can ameliorate depressive-like behaviors and metabolic abnormalities induced by corticosterone, which suggested that the multiple effects of resveratrol could be beneficial for patients with depression and/or metabolic syndrome associated with long-term glucocorticoid therapy.
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影响因子：
4.8
作者：
Fransson L;Dos Santos C;Wolbert P;Sjöholm A;Rafacho A;Ortsäter H
通讯作者：
Ortsäter H
影响因子：
6.3
作者：
Chimin, P.;Farias, T. da S. M.;Lima, F. B.
通讯作者：
Lima, F. B.
DOI：
10.1530/joe-14-0335
发表时间：
2014-11
期刊：
The Journal of endocrinology
影响因子：
--
作者：
Rouse M;Younès A;Egan JM
通讯作者：
Egan JM
影响因子：
25
作者：
Stranahan, Alexis M.;Arumugam, Thiruma V.;Mattson, Mark P.
通讯作者：
Mattson, Mark P.
影响因子：
3.5
作者：
Sadi, Gokhan;Pektas, Mehmet Bilgehan;Koca, Tulay
通讯作者：
Koca, Tulay