Predictors of neurodegeneration differ between cognitively normal and subsequently impaired older adults
Predictors of neurodegeneration differ between cognitively normal and subsequently impaired older adults
复制标题
DOI：
10.1016/j.neurobiolaging.2018.10.024
复制
发表时间：
2019-03-01
影响因子：
4.2
通讯作者：
Resnick, Susan M.
中科院分区：
文献类型：
--
作者：
Armstrong, Nicole M.;An, Yang;Resnick, Susan M.
阿尔茨海默病（AD）危险因素对脑容量变化的影响可能部分解释了在临床前AD阶段发生的事情，这些人随后发展为认知障碍（SI）。我们研究了在诊断认知障碍之前，通过基于MRI的体积损失测量的老年人神经退行性变的预测因素。1994年至2015年，623名认知正常的参与者和65名SI巴尔的摩老龄化纵向研究参与者（年龄55-92岁）入组了神经影像子研究。混合效应回归用于评估AD风险因素（年龄、APOE e4携带状态、糖尿病、高血压、肥胖、当前吸烟和胆固醇升高）与总体样本和诊断状态中脑区域体积变化的相关性。年龄较大、载脂蛋白E e4携带状态、高血压和高密度脂蛋白胆固醇是体积变化的预测因素。仅在SI参与者中，高血压、肥胖和APOE e4携带状态与选定脑区的较大下降相关。处于临床前AD阶段的SI个体易受在认知正常个体中具有保护性或无效作用的风险因素的影响。(C)2018爱思唯尔公司All rights reserved.
Effects of Alzheimer's disease (AD) risk factors on brain volume changes may partly explain what happens during the preclinical AD stage in people who develop subsequent cognitive impairment (SI). We investigated predictors of neurodegeneration, measured by MRI-based volume loss, in older adults before diagnosis of cognitive impairment. There were 623 cognitively normal and 65 SI Baltimore Longitudinal Study of Aging participants (age 55-92 years) enrolled in the neuroimaging substudy from 1994 to 2015. Mixed-effects regression was used to assess the associations of AD risk factors (age, APOE e4 carrier status, diabetes, hypertension, obesity, current smoking, and elevated cholesterol) with brain regional volume change among the overall sample and by diagnostic status. Older age, APOE e4 carrier status, hypertension, and HDL cholesterol were predictors of volumetric change. Among SI participants only, hypertension, obesity, and APOE e4 carrier status were associated with greater declines in selected brain regions. SI individuals in the preclinical AD stage are vulnerable to risk factors that have either a protective or null effect in cognitively normal individuals. (C) 2018 Elsevier Inc. All rights reserved.