Mitomycin C in photorefractive keratectomy - Effect on epithelialization and predictability
Mitomycin C in photorefractive keratectomy - Effect on epithelialization and predictability
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DOI：
10.1097/ico.0b013e31815c5a51
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发表时间：
2008-04-01
期刊：
影响因子：
2.8
通讯作者：
Leccisotti, Antonio
中科院分区：
文献类型：
--
作者：
Leccisotti, Antonio
目的：目的：探讨准分子激光屈光性角膜切削术（PRK）后局部应用丝裂霉素C（MMC）对角膜上皮化的影响及其可预测性。入选标准：双眼等效球镜（SE）为-6.5 ~-10 D，2眼SE相差520 μ m，2眼相差< 20 μ m，随访12个月。2眼的计划光学区相等。在手动深上皮化和准分子消融后，将用MMC 0.2 mg/mL或平衡盐溶液浸泡的Merocel海绵以随机方式放置在任一只眼睛的基质床上45秒。绷带接触透镜，直到上皮化;氟米龙0.1%滴眼液对称使用，并在2 eyes.Results锥形：52例患者（23名男性;平均年龄，33岁）完成了研究术前平均SE为-8.07 +/- 0.92 D MMC的眼睛和-7.96 +/- 0.81 D在对照眼（无统计学意义）。MMC眼的平均上皮形成时间为3.0 ± 0.69天，对照眼为3.0 ± 0.71天（无统计学显著性）。在12个月时，MMC眼的平均SE为0.47 +/- 0.43 D，对照眼为0.17 +/- 0.49 D（P < 0.05）。MMC眼的平均雾度为0.02 +/- 0.07，对照眼为0.19 +/- 0。结论：MMC在12个月时不延迟上皮形成，也不引起不良反应。MMC诱导平均0.47-D的过度矫正（5.8%的尝试矫正）。MMC治疗的所有眼均有混浊分级
Purpose: To evaluate the effect of topical mitomycin C (MMC) after myopic photorefractive keratectomy (PRK) on epithelialization and predictabilityMethods: Prospective, randomized, double-masked, same-day, paired eye study. Inclusion criteria: bilateral spherical equivalent (SE) between -6.5 and -10 D, difference of SE between the 2 eyes of 520 mu m, with a difference between the 2 eyes of < 20 mu m, follow-up 12 months. Planned optical zone was equal in the 2 eyes. After manual deepithelialization and excimer ablation, a Merocel sponge soaked either with MMC 0.2 mg/mL or with balanced salt solution was placed on the stromal bed of either eye for 45 seconds in a randomized fashion. A bandage contact lens was used until epithelialization; fluorometholone 0.1% eyedrops were symmetrically used and tapered in the 2 eyes.Results: Fifty-two patients (23 men; mean age, 33 years) completed the study Preoperative mean SE was -8.07 +/- 0.92 D in the MMC eyes and -7.96 +/- 0.81 D in the control eyes (not statistically significant). Mean epithelialization time was 3.0 +/- 0.69 days in the MMC eyes and 3.0 +/- 0.71 days in the control eyes (not statistically significant). At 12 months, mean SE was 0.47 +/- 0.43 D in the MMC eyes and 0.17 +/- 0.49 D in the control eyes (P < 0.05). Mean haze in the MMC eyes was 0.02 +/- 0.07 and in the control eyes was 0.19 +/- 0. 17 (P < 0.05).Conclusions: MMC did not delay epithelialization and did not induce adverse effects at 12 months. MMC induced a mean 0.47-D overcorrection (5.8% of attempted correction). All eyes treated with MMC had a haze grade