IMMUNOMODULATORY EFFECT OF PERIPHERAL BENZODIAZEPINE RECEPTOR LIGANDS ON HUMAN MONONUCLEAR-CELLS
IMMUNOMODULATORY EFFECT OF PERIPHERAL BENZODIAZEPINE RECEPTOR LIGANDS ON HUMAN MONONUCLEAR-CELLS
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DOI：
10.1016/0165-5728(92)90086-z
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发表时间：
1992-05-01
影响因子：
3.3
通讯作者：
DJALDETTI, M
中科院分区：
文献类型：
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作者：
BESSLER, H;WEIZMAN, R;DJALDETTI, M
在人外周血单个核细胞（PBMC）中检测外周苯二氮卓受体（PBR）活性配体的免疫调节作用。 Ro 5 -4864、PK 11195和安定抑制植物血凝素（PHA）和刀豆球蛋白A（ConA）诱导的PBMC增殖。 所有三种配体抑制白细胞介素-3-样活性（IL-3-LA）的分泌，而白细胞介素-2（IL-2）的产生被Ro 5 -4864和地西泮单独抑制。 选择性中枢苯二氮卓类配体氯硝西泮不影响细胞免疫功能检查。 我们的研究结果表明，在体外免疫抑制活性的外周和混合，但不是中央型苯二氮卓类配体。
Immunomodulatory effect of ligands active at the peripheral benzodiazepine receptor (PBR) was examined in human peripheral blood mononuclear cells (PBMC). Ro5-4864, PK11195 and diazepam suppressed phytohemagglutinin (PHA) and concanavalin A (ConA) induced proliferation of PBMC. All three ligands inhibited interleukin-3-like activity (IL-3-LA) secretion, while the production of interleukin-2 (IL-2) was inhibited by Ro5-4864 and diazepam only. The selective central benzodiazepine ligand clonazepam did not affect the cellular immune functions examined. Our results indicate an in-vitro immuno-suppressive activity of peripheral and mixed, but not central type benzodiazepine ligands.