Paradigms for glycan-binding receptors in cell adhesion
Paradigms for glycan-binding receptors in cell adhesion
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DOI：
10.1016/j.ceb.2007.09.004
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发表时间：
2007-10-01
影响因子：
7.5
通讯作者：
Drickarner, Kurt
中科院分区：
文献类型：
--
作者：
Taylor, Maureen E.;Drickarner, Kurt
在哺乳动物细胞表面发现的多种聚糖为聚糖特异性受体介导的细胞间选择性粘附提供了基础。众所周知，基于这种相互作用的细胞粘附的例子包括选择素介导的白细胞在内皮上的滚动。对细胞表面特定糖表位具有类似选择性的其他受体正在被表征。然而，一个细胞上的受体与另一个细胞上的聚糖结合而产生的粘附的简单范例仅适用于有限数量的系统。相反，聚糖和受体-聚糖相互作用通常以间接的方式调节粘附，例如通过改变细胞表面糖蛋白的组织和拮抗蛋白质粘附系统的作用。
Diverse glycans found on the surfaces of mammalian cells provide a basis for selective adhesion between cells mediated by glycan-specific receptors. Well-understood examples of cell adhesion based on such interactions include selectin-mediated rolling of leukocytes on endothelia. Other receptors with similar selectivity for specific sugar epitopes on cell surfaces are being characterised. However, the simple paradigm of adhesion resulting from receptors on one cell binding to glycans on another cell applies in only a limited number of systems. Instead, glycans and receptor-glycan interactions often modulate adhesion in indirect ways, such as by changing the organisation of cell surface glycoproteins and by antagonising the effect of protein adhesion systems.