Anisotropic Growth of Hydroxyapatite in Stretched Double Network Hydrogel
Anisotropic Growth of Hydroxyapatite in Stretched Double Network Hydrogel
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DOI：
10.1021/acsnano.7b04942
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发表时间：
2017-12-01
期刊：
影响因子：
17.1
通讯作者：
Gong, Jian Ping
中科院分区：
文献类型：
--
作者：
Fukao, Kazuki;Nonoyama, Takayuki;Gong, Jian Ping
骨组织由于具有各向异性结构的有机/无机物质的杂化而具有优异的力学性能，例如强度和柔性之间的相容性和承载性。为了综合模拟天然有机/无机杂化材料的各向异性结构，我们在拉伸坚韧双网络（DN）水凝胶中进行了羟基磷灰石（HAp）矿化。高亮度同步辐射X射线散射和透射电子显微镜观察显示，拉伸水凝胶中HAp发生各向异性矿化。矿化HAp的c轴沿沿着方向排列，从散射分布计算的取向度S随着DN凝胶的伸长率2的增加而增加，并且在λ = 4时S变得与兔胫骨的取向度相当。随着延伸率的增加，HAp多晶的形貌逐渐由球形变为单向棒状。提出了一种可能的各向异性矿化机理，这将是开发力学各向异性有机/无机杂化材料的关键之一。
Bone tissues possess excellent mechanical properties such as compatibility between strength and flexibility and load bearing owing to the hybridization of organic/inorganic matters with anisotropic structure. To synthetically mimic such an anisotropic structure of natural organic/inorganic hybrid materials, we carried out hydroxyapatite (HAp) mineralization in stretched tough double network (DN) hydrogels. Anisotropic mineralization of HAp took place in stretched hydrogels, as revealed by high brightness synchrotron X-ray scattering and transmission electron microscopic observation. The c-axis of mineralized HAp aligned along the stretching direction, and the orientation degree S calculated from scattering profiles increased with increasing in the elongation ratio 2 of the DN gel, and S at lambda = 4 became comparable to that of rabbit tibial bones. The morphology of HAp polycrystal gradually changed from spherical to unidirectional rod-like shape with increased elongation ratio. A possible mechanism for the anisotropic mineralization is proposed, which would be one of the keys to develop mechanically anisotropic organic/inorganic hybrid materials.