Maternal pre-pregnancy obesity and timing of puberty in sons and daughters: a population-based cohort study
Maternal pre-pregnancy obesity and timing of puberty in sons and daughters: a population-based cohort study
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DOI：
10.1093/ije/dyz125
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发表时间：
2019-10-01
影响因子：
7.7
通讯作者：
Ramlau-Hansen, Cecilia Host
中科院分区：
文献类型：
--
作者：
Brix, Nis;Ernst, Andreas;Ramlau-Hansen, Cecilia Host
背景：在许多国家，妊娠期肥胖患病率的增加与青春期年龄的下降相吻合。我们的目的是探讨母亲孕前超重和肥胖对儿子和女儿青春期时间的潜在影响。方法：在2012年至2018年期间，来自丹麦国家出生队列（2000- 2003年出生）的22439名儿童中，有15819名儿童提供了从11岁开始的青春期里程碑半年信息：发黄期、声音破裂、第一次射精、月经初潮、痤疮和腋毛。我们估计了暴露于母亲孕前肥胖[体重指数(BMI) >= 30.0kg/m(2)]或超重（BMI 25.0至29.9kg/m(2)）与正常体重（BMI 18.5至24.9 kg/m(2)）的儿童达到青春期里程碑年龄的调整平均月差异（95%置信区间）作为参考。在中介分析中，我们探讨了7岁儿童BMI是否介导了这种关联。结果：母亲孕前肥胖与儿子较早达到青春期发育阶段有关，孕前超重和肥胖与女儿较早达到青春期发育阶段有关。当综合所有青春期里程碑时，孕前肥胖[儿子：-1.5（-2.5,-0.4）个月；女儿：-3.2（-4.2,-2.1）个月]和超重[仅女儿：-2.6（-3.3,-1.8）个月]与青春期提前有关。男孩的这种关联完全由较高的儿童体重指数介导，而女孩的这种关联也有部分由较高的儿童体重指数介导。结论：母亲孕前肥胖似乎通过儿子的儿童期肥胖降低了青春期的时间，而主要是通过女儿的其他机制。
Background: In many countries, an increased prevalence of obesity in pregnancy has coincided with a declining pubertal age. We aimed to explore the potential effect of maternal pre-pregnancy overweight and obesity on timing of puberty in sons and daughters.Methods: Between 2012 and 2018, 15 819 of 22 439 invited children from the Danish National Birth Cohort, born 2000-03, provided half-yearly information from the age of 11 years on the pubertal milestones: Tanner stages, voice break, first ejaculation, menarche, acne and axillary hair. We estimated adjusted mean monthly differences (with 95% confidence intervals) in age at attaining the pubertal milestones for children exposed to maternal pre-pregnancy obesity [body mass index (BMI) >= 30.0kg/m(2)] or overweight (BMI 25.0 to 29.9kg/m(2)) with normal weight (BMI 18.5 to 24.9 kg/m(2)) as reference. In mediation analysis, we explored whether childhood BMI at age 7 years mediated the associations.Results: Maternal pre-pregnancy obesity was associated with earlier age at attaining most pubertal milestones in sons, and pre-pregnancy overweight and obesity were associated with earlier age at attaining all pubertal milestones in daughters. When combining all pubertal milestones, pre-pregnancy obesity [sons: -1.5 (-2.5, -0.4) months; daughters: -3.2 (-4.2, -2.1) months] and overweight [daughters only: -2.6 (-3.3, -1.8) months] were associated with earlier timing of puberty. The associations in sons were completely mediated by higher childhood BMI and partly so in daughters.Conclusions: Maternal pre-pregnancy obesity appears to lower timing of puberty through childhood obesity in sons and mainly through other mechanisms in daughters.