Meprins, membrane-bound and secreted astacin metalloproteinases.
Meprins, membrane-bound and secreted astacin metalloproteinases.
复制标题
DOI：
10.1016/j.mam.2008.08.002
复制
发表时间：
2008-10
影响因子：
10.6
通讯作者：
Bond, Judith S.
中科院分区：
文献类型：
--
作者：
Sterchi, Erwin E.;Stoecker, Walter;Bond, Judith S.
虾青素是金属蛋白酶metzincin超家族的一个亚家族。第一个被鉴定的是小龙虾的虾红素酶。到目前为止，已经在从细菌到人类的物种中确定了该家族的200多个成员。Astacins参与发育形态发生、基质组装、组织分化和消化。家族成员包括前胶原C蛋白酶（BMP 1，骨形态发生蛋白1），tolloid和哺乳动物tolloid样，HMP（水螅金属蛋白酶），海胆BP 10（囊胚蛋白）和SPAN（Strongylocentrotus purpuratus astacin），'孵化'亚科，包括alveolin、ovastacin、LCE、HCE（“低”和“高”绒毛膜溶解酶）、肾蛋白（来自鲤鱼头肾）、来自青蛙的UVS.2和meprins。在人类和小鼠基因组中，有6个astacin家族基因（2个meprins，3个BMP 1/tolloid样，1个ovastacin），但在秀丽隐杆线虫中有40个。由于它们可以被膜结合或分泌，所以Meprins是唯一在膜上和细胞外起作用的astacin蛋白酶。它们在结构域结构和共价亚基二聚化、寡聚化倾向和表达模式方面是独特的。它们通常在转录和翻译后水平高度调节，定位于特定的膜或细胞外空间，并且可以水解生物活性肽、细胞因子、细胞外基质（ECM）蛋白和细胞表面蛋白。meprins的体内底物尚不清楚，但这些蛋白酶在肠、肾和皮肤的上皮细胞中的丰富表达为其功能提供了线索。
The astacins are a subfamily of the metzincin superfamily of metalloproteinases. The first to be characterized was the crayfish enzyme astacin. To date more than 200 members of this family have been identified in species ranging from bacteria to humans. Astacins are involved in developmental morphogenesis, matrix assembly, tissue differentiation and digestion. Family members include the procollagen C-proteinase (BMP1, bone morphogenetic protein 1), tolloid and mammalian tolloid-like, HMP (Hydra vulgaris metalloproteinase), sea urchin BP10 (blastula protein) and SPAN (Strongylocentrotus purpuratus astacin), the ‘hatching’ subfamily comprising alveolin, ovastacin, LCE, HCE (‘low’ and ‘high’ choriolytic enzymes), nephrosin (from carp head kidney), UVS.2 from frog, and the meprins. In the human and mouse genomes, there are six astacin family genes (two meprins, three BMP1/tolloid-like, one ovastacin), but in Caenorhabditis elegans there are 40. Meprins are the only astacin proteinases that function on the membrane and extracellularly by virtue of the fact that they can be membrane-bound or secreted. They are unique in their domain structure and covalent subunit dimerization, oligomerization propensities, and expression patterns. They are normally highly regulated at the transcriptional and post-translational levels, localize to specific membranes or extracellular spaces, and can hydrolyse biologically active peptides, cytokines, extracellular matrix (ECM) proteins and cell-surface proteins. The in vivo substrates of meprins are unknown, but the abundant expression of these proteinases in the epithelial cells of the intestine, kidney and skin provide clues to their functions.
登录
查看更多内容
影响因子：
64.8
作者：
BODE, W;GOMISRUTH, FX;STOCKER, W
通讯作者：
STOCKER, W
影响因子：
3.7
作者：
Bylander, John E.;Bertenshaw, Greg P.;Bond, Judith S.
通讯作者：
Bond, Judith S.
影响因子：
4.8
作者：
Bertenshaw, GP;Turk, BE;Bond, JS
通讯作者：
Bond, JS
影响因子：
6.5
作者：
Becker-Pauly, Christoph;Hoewel, Markus;Stoecker, Walter
通讯作者：
Stoecker, Walter
影响因子：
5.8
作者：
Borchert, Nadine;Becker-Pauly, Christoph;Brattig, Norbert W.
通讯作者：
Brattig, Norbert W.