Elevated expression of PD-1 on T cells correlates with disease activity in rheumatoid arthritis
Elevated expression of PD-1 on T cells correlates with disease activity in rheumatoid arthritis
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DOI：
10.3892/mmr.2017.8204
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发表时间：
2018-02-01
影响因子：
3.4
通讯作者：
Li, Junming
中科院分区：
文献类型：
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作者：
Luo, Qing;Ye, Jianqing;Li, Junming
众所周知，淋巴细胞在类风湿性关节炎（RA）中很重要。程序性细胞死亡-1（PD-1）是免疫抑制共刺激分子之一，介导抑制作用。然而，其在 RA 中的作用仍有待充分阐明。在本研究中，使用流式细胞术测定外周血（PB）和滑液（SF）中T细胞上PD-1的表达水平。此外，进一步分析 RA 患者 PB 和 SF 中 T 细胞上 PD-1 的表达水平，以确定与 RA 自身免疫反应、炎症和疾病活动标志物的相关性。与健康对照相比，RA患者外周血T细胞上PD-1的表达显着升高（P
It is well known that lymphocytes are important in rheumatoid arthritis (RA). Programmed cell death-1 (PD-1) is one of the immunosuppressive costimulatory molecules, which mediates an inhibitory effect. However, its role in RA remains to be fully elucidated. In the present study, the expression levels of PD-1 on T cells in the peripheral blood (PB) and synovial fluid (SF) were determined using flow cytometry. In addition, the expression levels of PD-1 on T cells in the PB and SF of patients with RA were further analyzed to determine correlation with markers of the autoimmune response, inflammation and disease activity in RA. Compared with healthy controls, the expression of PD-1 on T cells in the PB was significantly elevated in patients with RA (P