Connection from cortical area V2 to MT in macaque monkey
Connection from cortical area V2 to MT in macaque monkey
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DOI：
10.1002/cne.10100
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发表时间：
2002-01-28
影响因子：
2.5
通讯作者：
Martin, KAC
中科院分区：
文献类型：
--
作者：
Anderson, JC;Martin, KAC
猕猴的外视区称为MT或V5，接收来自多个来源的输入。我们以前研究过V1细胞与MT之间的突触连接（Anderson et al., 1998）。在这里，我们对从V2到MT的投影进行了类似的分析。NIT中V2投影的主要目标是第4层，在那里它形成了不对称（兴奋性）突触簇。与VI投影不同的是，它也在第1层和第2层形成突触，而在第6层不形成突触。从V2标记的钮扣最常遇到的目标是脊柱（67%在第4层，82%在第2/3层）。不同寻常的是，在第一层中，只有5/12的钮扣真正形成了突触。与V1投影不同，多突触钮扣是罕见的（平均每个钮扣1.1个突触，而V1投影为1.7个）。像V1投影一样，从V2中任何一点到NIT的输入都是稀疏的（在第4层最密集的簇中贡献了大约4-6%的不对称突触）。V2突起的突触与V1突起的突触大小相似(0.1 μ m(2) vs. 0.09 μ m(2))，两者在棘上形成的突触后密度都比在树突轴上形成的突触后密度更复杂。V1和V2投影到MT的明显差异表明它们的功能是互补的，而不是完全重叠的。[j] .中华神经医学杂志，2002,31(3):557 - 557。(C) 2002 Wiley-Liss, Inc。
The extrastriate visual area of the macaque monkey called MT or V5, receives its input from multiple sources. We have previously examined the synaptic connections made by V1 cells that project to MT (Anderson et al., 1998). Here, we provide a similar analysis of the projection from V2 to MT. The major target of the V2 projection in NIT is layer 4, where it forms clusters of asymmetric (excitatory) synapses. Unlike the VI projection, it also forms synapses in layers 1 and 2 and does not form synapses in layer 6. The most frequently encountered targets of boutons labeled from V2 were spines (67% in layer 4; 82% in layer 2/3). Unusually, only 5/12 boutons examined in layer 1 actually formed synapses. Unlike the V1 projection, multisynaptic boutons were rare (mean, 1.1 synapses per bouton vs. 1.7 for the V1 projection). Like the V1 projection, the input to NIT from any point in V2 is sparse (contributing approximately 4-6% of the asymmetric synapses in the densest clusters in layer 4). The synapses of the V2 projection were similar in size to those of the V1 projection (0.1 mum(2) vs. 0.09 mum(2)) and both formed more complex postsynaptic densities on spines than on dendritic shafts. The clear differences between the V1 and V2 projection to MT indicate that their functions are complementary rather than completely overlapping. J. Comp. Neurol. 443: 56-70, 2002. (C) 2002 Wiley-Liss, Inc.