Beta-adrenergic blockade and central circulation during exercise in sitting position in healthy subjects.
Beta-adrenergic blockade and central circulation during exercise in sitting position in healthy subjects.
复制标题
健康受试者坐位运动期间的β-肾上腺素能阻断和中枢循环。
DOI：
10.1111/j.1365-201x.1968.tb10883.x
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发表时间：
1968
期刊：
影响因子：
--
通讯作者：
G. von Schmalensee
中科院分区：
文献类型：
--
作者：
C. Furberg;G. von Schmalensee
在8名健康的年轻男性中，研究了坐姿运动时β -肾上腺素能阻滞对中枢循环的影响。口服普萘洛尔后，剂量约为0.22毫克/公斤体重。运动时脉搏率、心输出量和肱动脉平均压均显著降低。肺动脉a-v氧差和平均压升高。在β -阻断期间，摄氧量和脑卒中容量均未发生系统性变化。服用心得安后，170脉冲时的体力工作能力平均提高15%。这种增加主要是通过更好的外周氧利用来实现的，并且只能在很小程度上解释为卒中量的增加。
The effect of a beta-adrenergic blockade on central circulation during exercise in a sitting position has been examined in 8 healthy young men. After oral administration of propranolol in doses of about 0.22 mg/kg b.wt. there were significant decreases in pulse rate, cardiac output and mean pressure in the brachial artery during exercise. An increase of a-v oxygen difference and of mean pressure in the pulmonary artery was noted. No systematic change was noted in oxygen uptake and stroke volume respectively during the beta-blockade. The physical working capacity at pulse 170 increased on an average by 15 % after propranolol. This increase was made possible primarily through a better peripheral oxygen utilization and could only be explained to a minor extent by an increase in stroke volume.