Regulation of 3-hydroxy-3-methylglutarate and mevalonate biosynthesis by rat liver homogenates. Effects of fasting, cholesterol feeding, and triton administration.
Regulation of 3-hydroxy-3-methylglutarate and mevalonate biosynthesis by rat liver homogenates. Effects of fasting, cholesterol feeding, and triton administration.
复制标题
大鼠肝匀浆对 3-羟基-3-甲基戊二酸和甲羟戊酸生物合成的调节。
DOI：
10.1021/bi00815a021
复制
发表时间：
1970
期刊：
影响因子：
2.9
通讯作者：
H. Rudney
中科院分区：
文献类型：
--
作者：
L. W. White;H. Rudney
方法组织的制备、中间体的分离和纯化以及分析方法已在先前详细描述（白色和Rudney，1970）。对照组动物随意喂食Purina大鼠颗粒和水。如有说明，动物禁食不同时间。喂食胆固醇的大鼠在饮食中接受1%的胆固醇，通过加入溶解在Escherichia coli大鼠颗粒中的胆固醇溶液并使溶剂蒸发来制备。Triton治疗的大鼠重新-
MethodsPreparation of tissues, separation and purification of in-termediates, and analytical methods have been previously detailed (White and Rudney, 1970). Control animals were fed Purina rat pellets and water ad libitum. Where indicated, animals were fasted for variable periods. Cholesterol-fed rats received 1% cholesterol in the diet, prepared by adding a solution of cholesterol dissolved in etherto rat pellets and allowing the solvent to evaporate. Triton-treated rats re-