CHANGES IN COCHLEAR MICROPHONIC AND NEURAL SENSITIVITY PRODUCED BY ACOUSTIC TRAUMA
CHANGES IN COCHLEAR MICROPHONIC AND NEURAL SENSITIVITY PRODUCED BY ACOUSTIC TRAUMA
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DOI：
10.1016/0378-5955(89)90090-7
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发表时间：
1989-05-01
期刊：
影响因子：
2.8
通讯作者：
JOHNSTONE, BM
中科院分区：
文献类型：
--
作者：
PATUZZI, RB;YATES, GK;JOHNSTONE, BM
本文测量了声过度刺激前后豚鼠耳蜗圆窗和第一回Corti器低频（200 Hz）微音电位。在响亮的声音后，这种微音的幅度的降低与该区域的神经阈值升高高度相关。颤噪振幅的下降是由于外毛细胞顶端的机械-电转导通道失活而进入闭合状态。这些结果与通过外毛细胞的电流控制Corti器官的机械敏感性的想法一致，并且在响亮的声音之后机械和神经敏感性的暂时丧失是由于机械-电转导通道的简单失活。
The low-frequency (200 Hz) microphonic potentials at the round window and in the organ of Corti of the first turn of the guinea pig cochlea have been measured before and after acoustic overstimulation. Reductions in the amplitude of this microphonic after loud sound are highly correlated with neural threshold elevation in this region. The fall in the microphonic amplitude appears due to an inactivation of mechano-electrical transduction channels at the apex of the outer hair cells into a closed state. These results are consistent with the idea that the current through the outer hair cells controls the mechanical sensitivity of the organ of Corti, and that the temporary loss of mechanical and neural sensitivity following loud sound is due to a simple inactivation of the mechano-electrical transduction channels.