Cranial placodes: Models for exploring the multi-facets of cell adhesion in epithelial rearrangement, collective migration and neuronal movements
Cranial placodes: Models for exploring the multi-facets of cell adhesion in epithelial rearrangement, collective migration and neuronal movements
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DOI：
10.1016/j.ydbio.2014.12.012
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发表时间：
2015-05-01
影响因子：
2.7
通讯作者：
Schneider-Maunoury, Sylvie
中科院分区：
文献类型：
--
作者：
Breau, Marie Anne;Schneider-Maunoury, Sylvie
形态发生的关键是胚胎中细胞运动的协调，这需要细胞与其封闭环境之间微调的粘附相互作用。神经嵴范例提供了重要的见解如何粘附动力学控制上皮间充质转化和间充质细胞迁移。关于颅基板，即产生脊椎动物感觉器官和神经节的重要部分的外胚层细胞的补丁，我们知道的要少得多。在这篇综述中，我们总结了已知的功能，粘附分子在颅基板形态发生，并讨论了潜在的新的影响，在这个关键的发展过程中的粘附相互作用。基板细胞行为的伟大剧目提供了新的途径，探索上皮重塑，集体迁移和神经元运动中的粘附复合物的多重作用。(C)2014爱思唯尔公司All rights reserved.
Key to morphogenesis is the orchestration of cell movements in the embryo, which requires fine-tuned adhesive interactions between cells and their close environment. The neural crest paradigm has provided important insights into how adhesion dynamics control epithelium-to-mesenchyme transition and mesenchymal cell migration. Much less is known about cranial placodes, patches of ectodermal cells that generate essential parts of vertebrate sensory organs and ganglia. In this review, we summarise the known functions of adhesion molecules in cranial placode morphogenesis, and discuss potential novel implications of adhesive interactions in this crucial developmental process. The great repertoire of placodal cell behaviours offers new avenues for exploring the multiple roles of adhesion complexes in epithelial remodelling, collective migration and neuronal movements. (C) 2014 Elsevier Inc. All rights reserved.