Illusory persistence of touch after right parietal damage: neural correlates of tactile awareness.
Illusory persistence of touch after right parietal damage: neural correlates of tactile awareness.
复制标题
右顶叶损伤后触觉的幻觉持续：触觉意识的神经相关性。
DOI：
10.1093/brain/awh347
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Patrik Vuilleumier
中科院分区：
文献类型：
--
作者：
S. Schwartz;F. Assal;N. Valenza;M. Seghier;Patrik Vuilleumier
我们研究了一名患者谁经历了“palinesssia”，持续触摸的错觉触觉刺激后，对左手，随后右顶叶脑膜瘤影响初级躯体感觉区的中央后回（SI）和上级顶叶回（布罗德曼区7），但保留次级躯体感觉皮层（SII）在上外侧沟。这种主观感觉伴随着触觉阈值的客观测量的短暂增加。该患者有轻度缺陷，在浅表触觉知觉，但表现出严重的左侧灭绝的偏移触觉刺激在双边刺激，但不是刺激的发作。功能磁共振成像显示增加的神经活动在palinesissia选择性地出现在同侧右侧SI皮层，但没有异常，在左侧SI和双边SII。右侧SI对左手上的新触觉刺激的开始有反应，但对它们的偏移没有反应。相比之下，任何一只手的触觉事件都能调制对侧SII区域的活动，甚至是未检测到的左侧偏移。这些数据表明，虚幻的持久性触摸刺激后的手可能会导致持续的神经活动在一个有限的区域的SI皮质持久的实际触觉刺激的偏移。这些发现也提供了直接的证据，SI在介导对侧身体部位的有意识体感体验中的关键作用。
We studied a patient who experienced 'palinaesthesia', an illusion of persistent touch following tactile stimulation on the left hand, subsequent to a right parietal meningioma affecting primary somatosensory regions in the postcentral gyrus (SI) and superior parietal gyrus (Brodmann area 7), but preserving the secondary somatosensory cortex (SII) in the upper lateral sulcus. This subjective sensation was accompanied by transient increases in objective measures of tactile threshold. The patient had mild deficits in superficial tactile perception, but showed severe left-sided extinction for offsets of tactile stimuli during bilateral stimulation, but not for onsets of stimuli. Functional MRI revealed increased neural activity during palinaesthesia selectively arising within the ipsilesional-right SI cortex, but no abnormality within left SI and bilateral SII. Right SI responded to the onset of new tactile stimuli on the left hand but not to their offset. By contrast, any tactile events on either hand modulated activity in contralateral SII regions, even undetected left-sided offsets. These data demonstrate that illusory persistence of touch following stimulation on the hand may result from sustained neural activity in a restricted region of the SI cortex outlasting the offset of the actual tactile stimuli. These findings also provide direct evidence for a critical role of SI in mediating conscious somatosensory experience on contralateral parts of the body.
影响因子：
56.9
作者：
PONS, TP;GARRAGHTY, PE;MISHKIN, M
通讯作者：
MISHKIN, M