PERIPHERAL AND INTRACEREBROVENTRICULAR ADMINISTRATION OF HUMAN CHORIONIC-GONADOTROPIN ALTERS SEVERAL HIPPOCAMPUS-ASSOCIATED BEHAVIORS IN CYCLING FEMALE RATS
PERIPHERAL AND INTRACEREBROVENTRICULAR ADMINISTRATION OF HUMAN CHORIONIC-GONADOTROPIN ALTERS SEVERAL HIPPOCAMPUS-ASSOCIATED BEHAVIORS IN CYCLING FEMALE RATS
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DOI：
10.1006/hbeh.1995.1004
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发表时间：
1995-03-01
影响因子：
3.5
通讯作者：
RAO, CV
中科院分区：
文献类型：
--
作者：
LUKACS, H;HIATT, ES;RAO, CV
我们最近在大鼠大脑中海马和齿状回中密度最高的黄体生成素 (LH)/人绒毛膜促性腺激素 (hCG) 受体的演示表明，促性腺激素在大脑内具有新的功能作用。本研究调查了 I-125-hCG 是否可以穿过血脑屏障到达海马，以及 hCG 在调节与大鼠海马形成相关的几种行为活动中的可能作用。外周注射的 I-125-hCG 中约有 1/100 以完整形式穿过血脑屏障，并在脑脊液和海马中发现。在骑自行车的雌性大鼠发情前期的早晨，腹膜内 (IF) 或脑室内 (ICV) 注射高度纯化的 hCG，会导致一些海马相关行为的变化。与注射盐水的对照动物相比，hCG 治疗的动物通常不太活跃，并且表现出较少的探索行为。然而，hCG 治疗组动物和对照动物之间进入开放区域的潜伏期没有差异。 IP 以及 ICV 注射 hCG 后，味觉恐惧症显着减少。 T 迷宫表现的记忆部分没有发现差异；然而，经过 hCG 治疗的大鼠表现出刻板行为减少。总之，hCG 可以穿过血脑屏障，并且 hCG 的外周或中枢给药会影响几种海马相关行为，表明海马 LH/hCG 受体最有可能参与介导这些作用。观察到的一些行为变化与孕妇有相似之处。 (C) 1995 年学术出版社
Our recent demonstration of receptors for luteinizing hormone (LH)/human chorionic gonadotropin (hCG) in rat brain with the highest density within the hippocampus and dentate gyrus suggests novel functional roles for gonadotropic hormones within the brain. The present study investigated whether I-125-hCG can cross the blood-brain barrier and reach hippocampus and the possible role of hCG in the regulation of several behavioral activities associated with the hippocampal formation in the rat. About 1/100th of peripherally injected I-125-hCG crossed the blood-brain barrier in an intact form and was found in cerebrospinal fluid and in hippocampus. Intraperitoneal (IF) or intracerebroventricular (ICV) injections of highly purified hCG on the morning of proestrus of cycling female rats resulted in changes in several hippocampus-associated behaviors. hCG-treated animals were generally less active and showed less exploratory behavior as compared to saline-injected control animals. There was no difference, however, in latency to enter the open field between hCG-treated and control animals. Taste neophobia was dramatically decreased following IP as well as ICV injection of hCG. No differences were found in the memory component of T-maze performance; however, the hCG-treated rats exhibited decreased stereotypic behavior. In summary, hCG can cross the blood-brain barrier, and peripheral or central administration of hCG affects several hippocampus-associated behaviors suggesting that hippocampal LH/hCG receptors are most likely involved in mediating these effects. Some of the observed behavioral changes have parallels in pregnant women. (C) 1995 academic Press, Inc.