Chronic recurrent angina.
Chronic recurrent angina.
复制标题
慢性反复发作的心绞痛。
DOI：
10.1097/00007611-197910000-00023
复制
发表时间：
1979
影响因子：
1.1
通讯作者：
D. Robertson
中科院分区：
文献类型：
--
作者：
R. Robertson;J. B. Breinig;D. Robertson
变异型心绞痛的自然史描述在一个病人的多次恶化和缓解在一段时间内数年。连续26天的住院心电图监测记录了569例ST段抬高事件，其中89%无症状。发作的持续时间从15秒到11分半钟不等，其中4%的发作与室性早搏有关。在住院期间，ST段抬高发作的频率和持续时间减少，疼痛发作也减少。在此期间，使用双盲交叉试验评估了多种治疗药物，包括普萘洛尔、消炎痛和扑尔敏。没有一种药物对病程有显著的有益影响，并且高剂量普萘洛尔的发作时间延长。由于这种疾病的病程具有很大的变异性，只有双盲交叉试验才能决定治疗药物的疗效。
The natural history of variant angina is described in a patient with multiple exacerbations and remissions over a period of several years. Constant in-hospital electrocardiographic monitoring for 26 days documented 569 episodes of ST elevation, 89% of which were asymptomatic. Episodes ranged in duration from 15 seconds to 11 1/2 minutes, with 4% of episodes associated with premature ventricular contractions. Over the course of hospitalization, the episodes of ST elevation decreased in frequency and length, as did episodes of pain. During this period, a number of therapeutic agents, including propranolol, indomethacin, and chlorpheniramine were evaluated using double-blind crossover trials. No agent had a significant beneficial effect on the course of the disease, and there was an increase in the length of episodes with high doses of propranolol. Because of the great variability in the course of this disease, only double-blind crossover trials should be allowed to dictate the efficacy of therapeutic agents.