Sensitive pepsin immunoassay for detection of laryngopharyngeal reflux
Sensitive pepsin immunoassay for detection of laryngopharyngeal reflux
复制标题
DOI：
10.1097/01.mlg.0000172043.51871.d9
复制
发表时间：
2005-08-01
期刊：
影响因子：
2.6
通讯作者：
Koufman, JA
中科院分区：
文献类型：
--
作者：
Knight, J;Lively, MO;Koufman, JA
目标/假设。目的探讨免疫法测定咽部痰液胃蛋白酶是否可作为检测喉咽炎的敏感、可靠的方法。与24小时双探头（食管和咽）pH监测相比，研究设计：接受pH监测的临床LPR患者在反流试验期间提供咽部痰液样本，使用酶联免疫吸附测定法进行胃蛋白酶测定。结果：胃蛋白酶测定结果从23个研究对象的63个咽喉痰标本进行了比较，其pH值监测数据。22%（14/63）的痰液样本中胃蛋白酶的存在与LPR（pH值）相关
Objectives/Hypothesis. To determine whether measurement of pepsin in throat sputum by immunoassay could be used as a sensitive and reliable method for detecting laryngopharyngeal. reflux (LPR) compared with 24-hour double-probe (esophageal and pharyngeal) pH monitoring. Study Design: Patients with clinical LPR undergoing pH monitoring provided throat sputum samples during the reflux-testing period for pepsin measurement using enzyme-linked immunoadsorbent assay. Results: Pepsin assay results from 63 throat sputum samples obtained from 23 study subjects were compared with their pH monitoring data. Twenty-two percent (14/63) of the sputum samples correlated the presence of pepsin with LPR (pH