LATERAL ENTORHINAL CORTICAL KINDLING CAN BE ESTABLISHED WITHOUT POTENTIATION OF THE ENTORHINAL GRANULE CELL SYNAPSE
LATERAL ENTORHINAL CORTICAL KINDLING CAN BE ESTABLISHED WITHOUT POTENTIATION OF THE ENTORHINAL GRANULE CELL SYNAPSE
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DOI：
10.1016/0014-4886(84)90083-9
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发表时间：
1984-01-01
影响因子：
5.3
通讯作者：
MCNAMARA, JO
中科院分区：
文献类型：
--
作者：
GIACCHINO, JL;SOMJEN, GG;MCNAMARA, JO
Kindling 是一种癫痫动物模型，涉及永久性增强的神经元对电刺激的反应。有人提出，兴奋性突触传递的长时程增强（LTP）是点燃的细胞基础。在通过 LEC 点燃的不受约束、未麻醉的大鼠中，检查从外侧内嗅皮层 (LEC) 到齿状颗粒细胞 (DG) 的单突触投射中的 LTP。在 LEC 点燃之前、期间和之后记录颗粒细胞的群体兴奋性突触后电位 (pEPSP)。对照组是与实验大鼠在同一时间段记录的未点燃的大鼠。尽管通过 LEC 进行了典型阶段的点燃，但在平台 pEPSP 振幅或初始斜率中没有发现一致的变化。引发 50% 最大或稳定 pEPSP 所需的刺激强度也没有显着变化。虽然点燃确实是通过刺激 LEC 建立的，但在发育过程中或点燃完成后，没有在颗粒细胞反应中检测到 LTP 的证据。 LTP 不是通过该途径点燃的机制的基础，或者它发生在接收 LEC 输入的不同大脑区域。
Kindling is an animal model of epilepsy which involves a permanently enhanced neuronal response to an electrical stimulus. It has been proposed that long-term potentiation (LTP) of excitatory synaptic transmission is the cellular basis of kindling. LTP was examined in the monosynaptic projections from the lateral entorhinal cortex (LEC) to dentate granule cells (DG) in unrestrained, unanesthetized rats kindled via the LEC. Population excitatory postsynaptic potentials (pEPSP) were recorded from the granule cells before, during, and after kindling of the LEC. Controls were unkindled rats recorded during the same time period as the experimental rats. No consistent changes were found in plateau pEPSP amplitudes or initial slopes although kindling via the LEC proceeded through the typical stages. There was also no significant change in the stimulus intensity needed to elicit a 50% maximal or plateau pEPSP. Whereas kindling was indeed established by stimulation of the LEC, there was no evidence of LTP detected in the granule cell response either during the development or after completion of kindling. Either LTP does not underlie the mechanism of kindling via this pathway or it occurs in different brain regions receiving LEC input.