The pond snail Lymnaea stagnalis.
The pond snail Lymnaea stagnalis.
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DOI：
10.1186/s13227-020-00169-4
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发表时间：
2020-12-04
期刊：
影响因子：
4.1
通讯作者：
Abe M
中科院分区：
文献类型：
--
作者：
Kuroda R;Abe M
淡水蜗牛Stagnalis有着悠久的研究历史，但直到最近才成为一种有吸引力的模式生物，用于研究发育生物学和转化医学领域的分子机制，如学习/记忆和神经退行性疾病。该物种的优势是雌雄同体，可以交叉和自我交配，这大大促进了遗传方法。建立身体旋向，或手性形态发生，是一个主要的研究课题，因为手性是明显的壳卷曲。手性是母系遗传的，直到最近，一种基因编辑方法才将肌动蛋白相关基因Lsdia 1确定为关键的手性决定因素。这篇短文回顾了自然栖息地，生命周期，主要研究问题和兴趣，以及实验方法。
The freshwater snail Lymnaea stagnalis has a long research history, but only relatively recently has it emerged as an attractive model organism to study molecular mechanisms in the areas of developmental biology and translational medicine such as learning/memory and neurodegenerative diseases. The species has the advantage of being a hermaphrodite and can both cross- and self-mate, which greatly facilitates genetic approaches. The establishment of body-handedness, or chiromorphogenesis, is a major topic of study, since chirality is evident in the shell coiling. Chirality is maternally inherited, and only recently a gene-editing approach identified the actin-related gene Lsdia1 as the key handedness determinant. This short article reviews the natural habitat, life cycle, major research questions and interests, and experimental approaches.
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影响因子：
16.6
作者：
Adema CM;Hillier LW;Jones CS;Loker ES;Knight M;Minx P;Oliveira G;Raghavan N;Shedlock A;do Amaral LR;Arican-Goktas HD;Assis JG;Baba EH;Baron OL;Bayne CJ;Bickham-Wright U;Biggar KK;Blouin M;Bonning BC;Botka C;Bridger JM;Buckley KM;Buddenborg SK;Lima Caldeira R;Carleton J;Carvalho OS;Castillo MG;Chalmers IW;Christensens M;Clifton S;Cosseau C;Coustau C;Cripps RM;Cuesta-Astroz Y;Cummins SF;di Stephano L;Dinguirard N;Duval D;Emrich S;Feschotte C;Feyereisen R;FitzGerald P;Fronick C;Fulton L;Galinier R;Gava SG;Geusz M;Geyer KK;Giraldo-Calderón GI;de Souza Gomes M;Gordy MA;Gourbal B;Grunau C;Hanington PC;Hoffmann KF;Hughes D;Humphries J;Jackson DJ;Jannotti-Passos LK;de Jesus Jeremias W;Jobling S;Kamel B;Kapusta A;Kaur S;Koene JM;Kohn AB;Lawson D;Lawton SP;Liang D;Limpanont Y;Liu S;Lockyer AE;Lovato TL;Ludolf F;Magrini V;McManus DP;Medina M;Misra M;Mitta G;Mkoji GM;Montague MJ;Montelongo C;Moroz LL;Munoz-Torres MC;Niazi U;Noble LR;Oliveira FS;Pais FS;Papenfuss AT;Peace R;Pena JJ;Pila EA;Quelais T;Raney BJ;Rast JP;Rollinson D;Rosse IC;Rotgans B;Routledge EJ;Ryan KM;Scholte LLS;Storey KB;Swain M;Tennessen JA;Tomlinson C;Trujillo DL;Volpi EV;Walker AJ;Wang T;Wannaporn I;Warren WC;Wu XJ;Yoshino TP;Yusuf M;Zhang SM;Zhao M;Wilson RK
通讯作者：
Wilson RK
影响因子：
4.6
作者：
Ford L;Crossley M;Williams T;Thorpe JR;Serpell LC;Kemenes G
通讯作者：
Kemenes G
影响因子：
2.7
作者：
Bouetard, Anthony;Noirot, Celine;Coutellec, Marie-Agnes
通讯作者：
Coutellec, Marie-Agnes
影响因子：
4.6
作者：
Abe, Masanori;Kuroda, Reiko
通讯作者：
Kuroda, Reiko
影响因子：
2.6
作者：
Henry, Jonathan Q.;Perry, Kimberly J.;Martindale, Mark Q.
通讯作者：
Martindale, Mark Q.