AUDIOLOGICAL FINDINGS IN YOUNG-PATIENTS WITH HYPOPHOSPHATEMIC BONE-DISEASE
AUDIOLOGICAL FINDINGS IN YOUNG-PATIENTS WITH HYPOPHOSPHATEMIC BONE-DISEASE
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DOI：
10.1177/000348948609500418
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发表时间：
1986-07-01
影响因子：
1.4
通讯作者：
WHYTE, MP
中科院分区：
文献类型：
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作者：
MEISTER, M;JOHNSON, A;WHYTE, MP
对19名低磷血症骨病患者进行了听力测试，以调查在受影响的成年人中报道的听力损伤是否发生在年轻患者中。在儿童或年轻成人患者中没有发现听力损失或显著的听觉发现。然而，三名年龄最大的受试者（40至58岁）被确定为耳蜗源性感音神经性听力损失，尽管其中两人的噪音暴露史可以解释这一观察结果。结果表明，如果低磷血症骨病和听力障碍之间存在关联，那么在接受治疗的患者中，听力症状直到成年后才会出现。需要对大量受影响的成年人进行进一步的研究，以确定听觉系统异常的发生率和机制，并评估药物治疗对代谢性骨病的任何影响。
Audiometric tests were conducted on 19 subjects with hypophosphatemic bone disease to investigate whether auditory impairment like that reported in affected adults occurs in young patients. No hearing loss or significant auditory findings were noted among the children or young adult patients. However, sensorineural hearing loss of cochlear origin was identified in the three oldest subjects (40 to 58 years), although a history of noise exposure in two of them could explain the observations. The results indicate that if an association exists between hypophosphatemic bone disease and hearing impairment, the auditory signs will not develop until adulthood in treated patients. Additional studies of large populations of affected adults are needed to identify the incidence and mechanism(s) of the auditory system abnormalities and to assess any effect of medical therapy for the metabolic bone disease.