FUNCTIONS OF HYALURONAN
FUNCTIONS OF HYALURONAN
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DOI：
10.1136/ard.54.5.429
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发表时间：
1995-05-01
影响因子：
27.4
通讯作者：
FRASER, JRE
中科院分区：
文献类型：
--
作者：
LAURENT, TC;LAURENT, UBG;FRASER, JRE
在上世纪中叶，据报道滑液中含有一种“粘蛋白”，它赋予了液体粘性和润滑特性。“1939年，Meyer等人将这种粘蛋白的粘性成分鉴定为透明质酸（透明质酸），这是一种先前从牛玻璃体中分离出来的多糖。 3 随后的工作主要集中于确定病理滑液中透明质酸的浓度和粘度，4-6 与正常滑液相比。与此同时，其他研究小组开始对滑膜透明质酸进行物理化学表征。 7 8 自从这项开创性工作以来，透明质酸在正常和病理条件下在关节中的作用不断引起人们的兴趣，特别是在引入关节内注射透明质酸治疗关节疾病之后。 9 自三十年代以来，我们已经获得了大量关于透明质酸的知识，但今天我们是否对其在关节中的真正功能了解更多？透明质酸的结构、物理化学性质和生物学经常被评论，读者可以参考这些文章。'0-'3
In the middle of the last century, synovial fluid had already been reported to contain a'mucin'which gave the fluid its viscosity and lubricating properties.'In 1939, Meyer et al2 identified the viscous component of this mucin as hyaluronan (hyaluronic acid), a polysaccha-ride previously isolated from the bovine vitreous body. 3 Subsequent work focused largely on determining the concentration of hyaluronan in, and the viscosity of, pathological synovial fluids'4-6 compared with normal fluids. At the same time, other research groups began a physicochemical characterisa-tion of synovial hyaluronan. 7 8 Ever since this pioneering work, the role of hyaluronan in the joint under normal and pathological conditions has continued to arouse interest, especially so after the introduction of intra-articular injections of hyaluronan in the treatment of joint disorders. 9 We have acquired a large amount of knowledge on hyaluronan since the thirties, but do we today know more about its real function in the joints? The structure, physical chemical properties and biology of hyaluronan have been frequently reviewed and the reader is referred to these articles.'0-'3