Induction of lung tumors in RFM mice after localized exposures to X rays or neutrons.
Induction of lung tumors in RFM mice after localized exposures to X rays or neutrons.
复制标题
RFM 小鼠局部暴露于 X 射线或中子后诱导肺部肿瘤。
作者：
R. Ullrich;M. C. Jernigan;L. Adams
本研究的目的是比较RFM小鼠胸部局部暴露于X射线或裂变中子后诱发肺肿瘤的剂量-反应关系。局部照射后9个月处死动物，清除其肺，并计数肿瘤以确定发病率百分比和肿瘤/小鼠。根据这些数据，肿瘤/小鼠和X射线剂量之间的关系可以通过具有浅初始斜率的线性二次模型或通过具有高于阈值剂量的剂量平方响应的阈值模型来充分描述，并且在0至900 rad的剂量范围内可以拒绝线性。对于中子，肿瘤/小鼠与0至25 rad范围内的剂量之间的关系可以通过线性或阈值模型来描述，其中线性响应高于阈值。在任何一种情况下，相对生物学效率增加，减少中子剂量从25在25拉德到40在10拉德。
The purpose of the present study was to compare the dose-response relationships for the induction of lung tumors in RFM mice after localized thoracic exposures to X rays or fission neutrons. Animals were killed 9 months after localized irradiation, their lungs were cleared, and the tumors were counted to determine both percentage incidence and tumors/mouse. From these data, the relationship between tumors/mouse and X-ray dose could be described adequately by a linear-quadratic model with a shallow initial slope, or by a threshold model with a dose-squared response above the threshold dose, and linearity could be rejected over the dose range of 0 to 900 rad. For neutrons the relationship between tumors/mouse and dose over the range of 0 to 25 rad could be described by a linear, or a threshold model with linear response above the threshold. In either case, the relative biological effectiveness increased with decreasing neutron dose from 25 at 25 rad to 40 at 10 rad.