Signaling with phosphoinositides: better than binary.
Signaling with phosphoinositides: better than binary.
复制标题
磷酸肌醇信号传导：比二元更好。
作者：
M. Overduin;M. Cheever;T. Kutateladze
当细胞外部受到刺激时，内部会产生一连串的信号。磷酸盐被洒在脂类和蛋白质上，它们在不同的信号通路中被识别。聚集在细胞表面之下以提供介导信号转导的磷酸标记的激酶已成为新一波药物设计的主要目标。肌醇磷脂信号呈现了一个特别耐人寻味的网络，它的许多谜团现在正在被解开。对特异性识别肌醇磷脂的蛋白质结构域的研究已经建立了S肌醇磷脂信号转导的第四、FYVE、PHOX和PLECKSTRIN同源结构域。
When the outside of cell is stimulated,the inside generates a flurry of signals. Phosphates are sprinkled over lipids and proteins,where they are recognized within diverse signaling pathways. The kinases that congregate beneath the cell surface to provide the phosphate tags that mediate signaling have become major targets of new wave of drug design. Phosphoinositide signaling presents a particularly intriguing network whose many mysteries are now being unlocked. Research into protein domains that specifically recognize phosphoinositides have established the ENTH, FYVE,Phox,and pleckstrin homology domains s four cornerstones of phosphoinositide signaling.