"Caveolated cells" characterized by deep surface invaginations and abundant filaments in mouse gastro-intestinal epithelia.
"Caveolated cells" characterized by deep surface invaginations and abundant filaments in mouse gastro-intestinal epithelia.
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“凹陷细胞”的特征是小鼠胃肠上皮细胞表面深层内陷和丰富的细丝。
DOI：
10.1002/aja.1001400203
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发表时间：
1974
期刊：
影响因子：
--
通讯作者：
C. P. Leblond
中科院分区：
文献类型：
--
作者：
A. Nabeyama;C. P. Leblond
对成年小鼠胃肠上皮细胞的光学和电子显微镜检查显示，广泛存在一种细胞类型，其特征在于深表面内陷或“小窝”，因此称为“小窝细胞”。
小窝细胞散在分布于胃、小肠和大肠的上皮细胞内，顶端狭窄，与腔相邻，基部较宽，与基底膜接触。在光学显微镜下，它们的微绒毛比附近的细胞更长;细胞质通常是苍白的，含有一组平行的原纤维，旁边是微小的光空间，可能对应于小窝。在电子显微镜下，发现每个原纤维由一束直丝组成，从微绒毛的核心向下延伸到核上区的较深部分;微管通常与这些丝相连。不同类型的花丝成束排列，围绕细胞的顶端区域从桥粒到桥粒。小窝是一条长而曲折的通道，开口于微绒毛之间的细胞表面，并延伸到细胞质深处。息肉样结构从小窝壁伸入管腔。据信，息肉的头部被释放到这个管腔中，在那里它们看起来像小球体。这些细胞又可能从小窝中出来，出现在微绒毛之间和旁边。
小窝细胞并不多，例如，它们在降结肠的隐窝中占不到1%的上皮细胞。它们可能存在于低分化细胞中的肠隐窝中，以及完全分化细胞中的胃和肠的表面。它们似乎经历更新，但由于它们在有丝分裂中没有出现，它们可能是由一些其他上皮细胞的分化引起的。
Light and electron microscope examination of gastro-intestinal epithelia in the adult mouse revealed the widespread presence of a cell type characterized by deep surface invaginations or “caveolae” and, accordingly, called “caveolated cell.”
The caveolated cells are scattered within the epithelia of stomach, small and large intestine; they have a narrow apex bordering the lumen and a wide base in contact with the basement membrane. In the light microscope, they display microvilli longer than in nearby cells; the cytoplasm is usually pale and contains an apical group of parallel fibrils, next to which are minute light spaces which may correspond to the caveolae. In the electron microscope, each fibril is found to be composed of a bundle of straight filaments, extending from the core of a microvillus down into the deeper portion of the supranuclear region; microtubules are often associated with these filaments. Filaments of a different type are arranged in bundles which go from desmosome to desmosome around the apical region of the cell. The caveolae are long and tortuous channels opening at the cell surface between the microvilli and extending deep into the cytoplasm. From the walls of caveolae, polyp-like structures project into the lumen. The heads of the polyps are believed to be released into this lumen where they appear as small spheres. These in turn may come out of the caveolae to appear between and next to the microvilli.
Caveolated cells are not numerous, e.g., they make up less than 1% of the epithelial cells in the crypts of descending colon. They may be found in the intestinal crypts among poorly differentiated cells, and at the surface of stomach and intestine among fully differentiated cells. They appear to undergo renewal, but since they have not been seen in mitosis, they probably arise from the differentiation of some other epithelial cells.