An overview of HCV molecular biology, replication and immune responses.
An overview of HCV molecular biology, replication and immune responses.
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DOI：
10.1186/1743-422x-8-161
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发表时间：
2011-04-11
期刊：
影响因子：
4.8
通讯作者：
Riazuddin S
中科院分区：
文献类型：
--
作者：
Ashfaq UA;Javed T;Rehman S;Nawaz Z;Riazuddin S
丙型肝炎病毒（HCV）引起急性和慢性肝炎，最终可导致永久性肝损伤，肝细胞癌和死亡。目前，由于高度的毒株变异，没有疫苗可用于预防HCV感染。目前的治疗护理，聚乙二醇干扰素α联合利巴韦林是昂贵的，有显着的副作用，并未能治愈约一半的所有感染。本文综述了HCV的分子病毒学、复制和免疫应答，并讨论了HCV如何逃避适应性免疫和体液免疫应答。这一新的认识将有助于丙型肝炎疫苗的研制以及从合成化学和天然来源中发现新的药物。
Hepatitis C virus (HCV) causes acute and chronic hepatitis which can eventually lead to permanent liver damage, hepatocellular carcinoma and death. Currently, there is no vaccine available for prevention of HCV infection due to high degree of strain variation. The current treatment of care, Pegylated interferon α in combination with ribavirin is costly, has significant side effects and fails to cure about half of all infections. In this review, we summarize molecular virology, replication and immune responses against HCV and discussed how HCV escape from adaptive and humoral immune responses. This advance knowledge will be helpful for development of vaccine against HCV and discovery of new medicines both from synthetic chemistry and natural sources.