Dysprosium and Holmium Vanadate Nanoprobes as High- Performance Contrast Agents for High-Field Magnetic Resonance and Computed Tomography Imaging
Dysprosium and Holmium Vanadate Nanoprobes as High- Performance Contrast Agents for High-Field Magnetic Resonance and Computed Tomography Imaging
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DOI：
10.1021/acs.inorgchem.0c02601
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发表时间：
2021-01-04
影响因子：
4.6
通讯作者：
Ocana, Manuel
中科院分区：
文献类型：
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作者：
Gomez-Gonzalez, Elisabet;Nunez, Nuria O.;Ocana, Manuel
我们描述了一种湿化学方法，用于合成均匀且分散良好的钒酸镝 (DyVO4) 和钒酸钬 (HoVO4) 纳米颗粒，其形状几乎为球形，平均尺寸约为 60 nm，并用聚丙烯酸对其进行功能化。基于磁化率和磁化强度测量，分析了两个系统在 9.4 T 下的横向磁弛豫率，以评估它们作为高场 MRI 造影剂的应用潜力。此外，还研究了这些系统的 X 射线衰减特性，以确定它们作为计算机断层扫描造影剂的能力。最后，还研究了生理 pH 条件下的胶体稳定性和功能化纳米粒子的细胞毒性，以评估其对生物成像应用的适用性。
We describe a wet chemical method for the synthesis of uniform and well-dispersed dysprosium vanadate (DyVO4) and holmium vanadate (HoVO4) nanoparticles with an almost spherical shape and a mean size of similar to 60 nm and their functionalization with poly(acrylic acid). The transverse magnetic relaxivity of both systems at 9.4 T is analyzed on the basis of magnetic susceptibility and magnetization measurements in order to evaluate their potential for application as high-field MRI contrast agents. In addition, the X-ray attenuation properties of these systems are also studied to determine their capabilities as computed tomography contrast agent. Finally, the colloidal stability under physiological pH conditions and the cytotoxicity of the functionalized NPs are also addressed to assess their suitability for bioimaging applications.