Migrating and myelinating potential of subventricular zone neural progenitor cells in white matter tracts of the adult rodent brain
Migrating and myelinating potential of subventricular zone neural progenitor cells in white matter tracts of the adult rodent brain
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DOI：
10.1016/j.mcn.2006.01.004
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发表时间：
2006-04-01
影响因子：
3.5
通讯作者：
Durbec, P
中科院分区：
文献类型：
--
作者：
Cayre, M;Bancila, M;Durbec, P
脑室下区（SVZ）的成体神经干细胞产生神经元祖细胞，这些神经元祖细胞沿着吻部[迁移流（RMS）]迁移并产生嗅觉中间神经元。在这里，我们评估的迁移潜力SVZ细胞外的RMS和他们的能力，以产生少突胶质细胞在成年人的大脑。我们发现，SVZ细胞迁移到长距离时，移植到白色物质束，如扣带（Ci）和胼胝体（CC）。此外，注射后22天，大多数呈现形态学和表型特征的细胞致力于少突胶质细胞谱系。移植到颤抖的CC和Ci中的细胞成为MBP阳性的少突胶质细胞，数量丰富，使这些白色物质束形成髓鞘。A型祖细胞参与这种髓鞘形成过程。总之，这项研究揭示了SVZ细胞在新环境中的迁移和髓鞘形成潜力。因此，SVZ细胞是脱髓鞘疾病新的治疗策略的开发的有趣的候选者。(c)2006爱思唯尔公司All rights reserved.
Adult neural stem cells in the subventricular zone (SVZ) produce neuronal progenitors that migrate along the rostra[ migratory stream (RMS) and generate olfactory interneurons. Here, we evaluate the migratory potential of SVZ cells outside the RMS and their capacity to generate oligodendrocytes in the adult brain. We show that SVZ cells migrate long distances when grafted into white matter tracts such as the cingulum (Ci) and corpus callosum (CC). Furthermore, 22 days postinjection, most present morphologic and phenotypic characteristics of cells committed to the oligodendrocyte lineage. Cells grafted in shiverer CC and Ci become MBP-positive oligodendrocytes, abundant, myelinating these white matter tracts. Type A progenitors are involved in this myelinating process. Altogether, this study reveals the migrating and myelinating potential of SVZ cells in a new environmental context. Therefore, SVZ cells stand as interesting candidates for the development of novel therapeutic strategies for demyelinating diseases. (c) 2006 Elsevier Inc. All rights reserved.