DOPAMINE NEURONS OF THE MONKEY MIDBRAIN - CONTINGENCIES OF RESPONSES TO STIMULI ELICITING IMMEDIATE BEHAVIORAL REACTIONS
DOPAMINE NEURONS OF THE MONKEY MIDBRAIN - CONTINGENCIES OF RESPONSES TO STIMULI ELICITING IMMEDIATE BEHAVIORAL REACTIONS
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DOI：
10.1152/jn.1990.63.3.607
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发表时间：
1990-03-01
影响因子：
2.5
通讯作者：
ROMO, R
中科院分区：
文献类型：
--
作者：
SCHULTZ, W;ROMO, R
1.本研究调查的行为条件下，多巴胺（DA）神经元的黑质和毗邻地区A8和A10的视觉和听觉触发刺激引起立即手臂和眼睛运动的反应与冲动。2.在正式任务中，快速打开位于动物眼前水平的装有食物的小盒子的门作为可见和可听的触发刺激。对侧的大多数DA神经元对此刺激作出反应，具有短脉冲串，中值起始潜伏期为50 ms，持续时间为90 ms（164个神经元中的75%）。在同侧任务执行过程中，在相当比例的DA神经元中观察到类似的反应，这表明反应对于所使用的肢体不是特异性的。3.当开门刺激的感觉成分被分离时，DA神经元通常以类似的方式对开门的移动视觉刺激、开门的低强度滑动噪声和开门时从远处发出的90-92 dB强度的1 kHz声音做出反应。单独对每一个组成部分的反应程度低于对所有三个组成部分的反应程度。4.在任务的一个变体中，一个相邻的、相同的食物盒与另一个盒子随机交替打开，但不允许动物伸出手（不对称的、直接反应的去/不去任务）。对于每一种感觉成分，DA神经元通常都会对go和no-go框的打开做出反应。在围棋测试中，当刺激引起肢体运动时，反应会增强。5.在大多数的去和不去试验中，猴子对开门的反应是目标导向的扫视眼球运动。神经元的反应，同样存在于偶尔没有眼球运动。因此，反应对于开始单独的手臂或眼睛运动不是特异性的。6.当相同的刺激发生在行为任务之外，缺乏目标直接的手臂和眼睛运动时，神经元反应不存在。这表明反应不是纯粹的感官性质，而是与刺激引起行为反应的能力有关。7.在go/no-go任务的变体中，在开门前2-3 s，指示灯亮起，使动物准备在开门时进行伸展运动或避免移动（不对称、依赖于预防的go/no-go任务）。（400字处截断摘要）
1. This study investigates the behavioral conditions in which dopamine (DA) neurons of substantia nigra and adjoining areas A8 and A10 respond with impulses to visual and auditory trigger stimuli eliciting immediate arm- and eye-movement reactions. 2. In a formal task, the rapid opening of the door of a small, food-containing box located at eye level ahead of the animal served as visible and audible trigger stimulus. Most DA neurons on the contralateral side responded to this stimulus with a short burst of impulses with median onset latency of 50 ms and duration of 90 ms (75% of 164 neurons). Similar responses were seen in a comparable fraction of DA neurons during ipsilateral task performance, suggesting that responses were not specific for the limb being used. 3. When the sensory components of the door opening stimulus were separated, DA neurons typically responded in a similar manner to the moving visual stimulus of the opening door, the low-intensity sliding noise of the opening door, and the 1-kHz sound of 90-92 dB intensity emitted from a distant source at the onset of door opening. Responses to each component alone were lower in magnitude than to all three together. 4. In a variation of the task, a neighboring, identical food box opened in random alternation with the other box but without permitting animals to reach out (asymmetric, direct-reaction go/no-go task). With each sensory component, DA neurons typically responded both to opening of go and no-go boxes. Responses were enhanced when stimuli elicited limb movements in go trials. 5. Monkeys reacted to door opening with target-directed saccadic eye movements in the majority of both go and no-go trials. Neuronal responses were equally present during the occasional absence of eye movements. Thus responses were not specific for the initiation of individual arm or eye movements. 6. Neuronal responses were absent when the same stimuli occurred outside of the behavioral task with target-direct arm and eye movements lacking. This shows that responses were not of purely sensory nature but were related to the capacity of the stimulus for eliciting behavioral reactions. 7. In a variation of the go/no-go task, an instruction light illuminated 2-3 s before door opening prepared the animal to perform the reaching movement on door opening or to refrain from moving (asymmetric, instruction-dependent go/no-go task).(ABSTRACT TRUNCATED AT 400 WORDS)