Animal modeling of lower urinary tract dysfunction associated with multiple sclerosis: Part I: Justification of the mouse model for MS research.
Animal modeling of lower urinary tract dysfunction associated with multiple sclerosis: Part I: Justification of the mouse model for MS research.
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DOI：
10.1002/nau.24649
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发表时间：
2021-04
影响因子：
2
通讯作者：
Smith PP
中科院分区：
文献类型：
--
作者：
Ramasamy R;Smith PP
在大多数多发性硬化症（MS）患者中，下尿路症状和功能障碍（LUTS/LUTD）导致生活质量下降、发病率和需要医疗干预。虽然MS是一种炎症性神经退行性疾病，但包括失禁控制障碍在内的临床表现传统上被认为是由于神经退行性疾病导致的神经信号丧失。MS-LUTS/LUTD的临床方法主要集中在尿动力功能障碍的背景下解决症状，因为病理生理学的理解是不完整的。小鼠模型为发现更详细的分子、细胞和组织水平的疾病及其临床表现提供了有用的研究平台。这两部分综述的目的是为多发性硬化症小鼠模型的研究提供最新进展，重点是下尿路症状。第一部分综述了目前对MS病理生理的认识、对下尿路症状的影响，并简要介绍了MS研究常用的小鼠模型类型。第二部分介绍了目前MS研究常用的动物模型、机制、与MS- luts /LUTD的相关性及其泌尿病理生理、优缺点。
Lower urinary tract symptoms and dysfunction (LUTS/LUTD) contribute to loss of quality of life, morbidity, and need for medical intervention in most patients with Multiple Sclerosis (MS). Although MS is an inflammatory neurodegenerative disease, clinical manifestations including continence control disorders have traditionally been attributed to loss of neural signaling due to neurodegeneration. Clinical approaches to MS-LUTS/LUTD have focused on addressing symptoms in the context of urodynamic dysfunctions as pathophysiologic understandings are incomplete. The mouse model provides a useful research platform for discovery of more detailed molecular, cellular, and tissue-level knowledge of the disease and its clinical manifestations. The aim of this two-part review is to provide a state-of-the-art update on the use of the mouse model for multiple sclerosis research, with a focus on lower urinary tract symptoms. Part I presents a summary of current understanding of MS pathophysiology, the impact on lower urinary tract symptoms, and briefly introduces the types of mouse models available to study MS. Part II presents the common animal models that are currently available to study MS, their mechanism, relevance to MS-LUTS/LUTD and their urinary pathophysiology, advantages and disadvantages.
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影响因子：
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作者：
Bo, Lars;Geurts, Jeroen J. G.;Barkhof, Frederik
通讯作者：
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影响因子：
11
作者：
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影响因子：
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通讯作者：
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DOI：
10.1093/jnen/62.7.723
发表时间：
2003-07-01
影响因子：
3.2
作者：
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通讯作者：
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影响因子：
6.6
作者：
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