Mechanical buckling of artery under pulsatile pressure.
Mechanical buckling of artery under pulsatile pressure.
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DOI：
10.1016/j.jbiomech.2012.01.035
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发表时间：
2012-04-30
影响因子：
2.4
通讯作者：
Han HC
中科院分区：
文献类型：
--
作者：
Liu Q;Han HC
经常发生在颈动脉和其他动脉的曲折现象已被证明与高血压、动脉粥样硬化和其他疾病有关。然而，曲折发展的机制尚不清楚。我们以前的研究表明，动脉屈曲可能是弯曲形状形成的一种可能机制，但脉动流条件下的动脉屈曲还没有得到充分的研究。本研究的目的是从实验和理论上确定脉动压力下动脉的临界屈曲压力，并阐明脉动流、恒定流和静压下的临界压力之间的关系。我们首先测试了猪颈动脉在这些载荷条件下的屈曲压力，然后提出了一个非线性弹性动脉模型来研究脉动压力条件下的屈曲压力。实验结果表明，在脉动压力作用下，当峰值压力近似等于静压作用下的临界屈曲压力时，动脉发生屈曲。在低脉冲频率下的模型模拟也证实了这一点。我们的结果为预测脉动压力下的动脉屈曲压力提供了一种有效的工具。
Tortuosity that often occurs in carotid and other arteries has been shown to be associated with high blood pressure, atherosclerosis, and other diseases. However the mechanisms of tortuosity development are not clear. Our previous studies have suggested that arteries buckling could be a possible mechanism for the initiation of tortuous shape but artery buckling under pulsatile flow condition has not been fully studied. The objectives of this study were to determine the artery critical buckling pressure under pulsatile pressure both experimentally and theoretically, and to elucidate the relationship of critical pressures under pulsatile flow, steady flow, and static pressure. We first tested the buckling pressures of porcine carotid arteries under these loading conditions, and then proposed a nonlinear elastic artery model to examine the buckling pressures under pulsatile pressure conditions. Experimental results showed that under pulsatile pressure arteries buckled when the peak pressures were approximately equal to the critical buckling pressures under static pressure. This was also confirmed by model simulations at low pulse frequencies. Our results provide an effective tool to predict artery buckling pressure under pulsatile pressure.