PRIMARY STRUCTURE OF SQUID SODIUM-CHANNEL DEDUCED FROM THE COMPLEMENTARY-DNA SEQUENCE
PRIMARY STRUCTURE OF SQUID SODIUM-CHANNEL DEDUCED FROM THE COMPLEMENTARY-DNA SEQUENCE
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DOI：
10.1016/s0006-291x(05)80775-2
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发表时间：
1992-07-15
影响因子：
3.1
通讯作者：
MATSUMOTO, G
中科院分区：
文献类型：
--
作者：
SATO, C;MATSUMOTO, G
通过互补 DNA 的克隆和序列分析，推导出来自鱿鱼 Loligo bleekeri 的钠通道的完整氨基酸序列。推导的序列揭示了与脊椎动物钠通道蛋白几乎相同的组织；包含所有六种跨膜结构的四个同源结构域与不同大小的连接体串联重复。鱿鱼钠通道的一个独特特征是 1,522 个残基序列，大约是大鼠钠通道 I、II 和 III 的四分之三。
The complete amino acid sequence of a sodium channel from squidLoligo bleekerihas been deduced by cloning and sequence analysis of the complementary DNA. The deduced sequence revealed an organization virtually identical to the vertebrate sodium channel proteins; four homologous domains containing all six membrane-spanning structures are repeated in tandem with connecting linkers of various sizes. A unique feature of the squid Na channel is the 1,522 residue sequence, approximately three fourths of those of the rat sodium channels I, II and III.