Mechanisms underlying phase lag between systemic arterial blood pressure and cerebral blood flow velocity
Mechanisms underlying phase lag between systemic arterial blood pressure and cerebral blood flow velocity
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DOI：
10.1159/000072564
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发表时间：
2003-01-01
影响因子：
2.9
通讯作者：
Hu, HH
中科院分区：
文献类型：
--
作者：
Kuo, TBJ;Chern, CM;Hu, HH
为了探讨动脉血压（ABP）和脑血流速度（CBFV）振荡之间相位滞后的机制，对正常志愿者仰卧位安静时的ABP和CBFV信号进行了无创记录。通过积分的方法逐搏计算平均ABP（MAP）和CBFV（MFV）。用MAP除以MFV计算脑血管阻力（CVR）。MAP、MFV和CVR信号的频域分析揭示了极低频（VLF，0.016-0.04 Hz）、低频（LF，0.04-0.15 Hz）和高频（HF，0.15-0.4 Hz）分量。在LF和HF范围内的MAP-CVR耦合的转移相位是频率依赖性的，这相当于2 s的时间延迟。然而，在CVR-MFV耦合中的转移相位不同，因为相位在LF和HF范围内分布在180度左右。交叉相关分析显示MAP-CVR耦合之间呈正相关，MAP领先2s，CVR-MFV耦合之间呈负相关，CVR领先0.3s。我们的结论是，ABP和CBFV振荡之间的相位滞后主要是由脑自动调节（即脑血管运动，显示MAP-CVR耦合）的起始潜伏期。此外，CVR-MFV耦合的负相关性可以为CBFV-ABP振荡相位领先的生理意义提供不同的解释。版权所有（C）2003 S. Karger AG，巴塞尔。
To explore the mechanisms underlying the phase lag between oscillations in arterial blood pressure (ABP) and cerebral blood flow velocity (CBFV), ABP and CBFV signals were recorded noninvasively from normal volunteers who lay quietly in a supine position. Mean ABP (MAP) and CBFV (MFV) were Calculated beat-to-beat by means of integration. Cerebral vascular resistance (CVR) was calculated by dividing MAP with MFV. Frequency domain analysis of MAP, MFV and CVR signals revealed very-low frequency (VLF, 0.016-0.04 Hz), low-frequency (LF, 0.04-0.15 Hz), and high-frequency (HF, 0.15-0.4 Hz) components. The transfer phase of MAP-CVR coupling in the LF and HF range was frequency-dependent, which is equivalent to a time delay of 2 s. However, the transfer phase differed in the CVR-MFV coupling in that the phase was distributed around 180degrees across the LF and HF ranges. Cross-correlation analysis revealed a positive relationship between MAP-CVR coupling, with MAP leading by 2 s, and a negative relationship between CVR-MFV coupling, with CVR leading by 0.3 s. We concluded that the phase lag between oscillations in ABP and CBFV was chiefly contributed to by the starting latency of cerebral autoregulation (i.e. cerebral vasomotion, revealed by MAP-CVR coupling). Moreover, the negative correlation of the CVR-MFV coupling could offer a different explanation for the physiologic significance of the phase lead of CBFV-ABP oscillations. Copyright (C) 2003 S. Karger AG, Basel.