Intracerebroventricular administration of nocistatin reduces inflammatory hyperalgesia in rats
Intracerebroventricular administration of nocistatin reduces inflammatory hyperalgesia in rats
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脑室内给予诺西他汀可减少大鼠炎症性痛觉过敏
DOI：
10.1016/s0304-3940(99)00202-5
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发表时间：
1999
影响因子：
2.5
通讯作者：
M. Satoh
中科院分区：
文献类型：
--
作者：
T. Nakagawa;M. Kaneko;Shogo Inamura;M. Satoh
Nocistatin 是一种从前伤害感受肽 (prepronociceptin) 衍生的生物活性肽，据报道，其鞘内给药可减少伤害感受肽 (nociceptin) 或前列腺素 E2 诱导的小鼠痛觉过敏和异常性疼痛。在这项研究中，我们研究了在大鼠爪压试验中脑室内（i.c.v.）注射诺西他汀对后肢足底注射角叉菜胶/高岭土诱导的炎症性痛觉过敏的影响。脑室内给予诺西他汀（0.5-50 pmol/大鼠）可剂量依赖性地减少角叉菜胶/高岭土诱导的痛觉过敏，该痛觉过敏在 15-30 m 处达到峰值。然而，i.c.v.给予诺西他汀（50 pmol/大鼠）对非炎症大鼠的伤害感受阈值没有影响。这些结果表明诺西他汀对角叉菜胶/高岭土在脊髓上水平诱导的炎症性痛觉过敏具有抗痛觉过敏作用。
Nocistatin is a biologically active peptide derived from prepronociceptin, and its intrathecal administration has been reported to reduce nociceptin- or prostaglandin E2-induced hyperalgesia and allodynia in mice. In this study, we investigated the effects of intracerebroventricular (i.c.v.) administration of nocistatin on the inflammatory hyperalgesia induced by hindlimb intraplantar injection of carrageenan/kaolin in the rat paw-pressure test. Intracerebroventricular administration of nocistatin (0.5–50 pmol/rat) dose-dependently reduced carrageenan/kaolin-induced hyperalgesia, which peaked at 15–30 m. However, i.c.v. administration of nocistatin (50 pmol/rat) had no effect on the nociceptive threshold of non-inflamed rats. These results indicate that nocistatin has anti-hyperalgesic effects on the inflammatory hyperalgesia induced by carrageenan/kaolin at the supraspinal level.
孤啡肽 FQ 前体的一级结构和组织分布。
DOI：
10.1073/pnas.93.16.8677
发表时间：
1996
影响因子：
11.1
作者：
Nothacker,HP;Reinscheid,RK;Mansour,A;Henningsen,RA;Ardati,A;MonsmaJr,FJ;Watson,SJ;Civelli,O
通讯作者：
Civelli,O