Exosomes and Nanoengineering: A Match Made for Precision Therapeutics
Exosomes and Nanoengineering: A Match Made for Precision Therapeutics
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DOI：
10.1002/adma.201904040
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发表时间：
2019-09-18
影响因子：
29.4
通讯作者：
Duan, Wei
中科院分区：
文献类型：
--
作者：
Tran, Phuong H. L.;Xiang, Dongxi;Duan, Wei
用于精准纳米医学的靶向外泌体递送系统引起了分子细胞生物学、制药科学和纳米工程领域的广泛兴趣。外泌体是天然衍生的 50-150 nm 纳米囊泡，在细胞间和/或细胞间组织通讯和跨物种通讯中发挥重要作用。外泌体也是一类有前途的新型药物递送载体，因为它们能够保护其有效负载免受化学和酶降解，以及逃避免疫系统的识别和随后的去除。与一类被称为适体或化学抗体的新型亲和配体相结合，分子靶向外泌体有望成为精准医学的下一代巧妙设计的纳米囊泡。在此，总结了由适体设计的靶向外泌体递送系统的最新进展，以用于未来利用此类人源纳米囊泡促进人类健康的策略。
Targeted exosomal delivery systems for precision nanomedicine attract wide interest across areas of molecular cell biology, pharmaceutical sciences, and nanoengineering. Exosomes are naturally derived 50-150 nm nanovesicles that play important roles in cell-to-cell and/or cell-to-tissue communications and cross-species communication. Exosomes are also a promising class of novel drug delivery vehicles owing to their ability to shield their payload from chemical and enzymatic degradations as well as to evade recognition by and subsequent removal by the immune system. Combined with a new class of affinity ligands known as aptamers or chemical antibodies, molecularly targeted exosomes are poised to become the next generation of smartly engineered nanovesicles for precision medicine. Here, recent advances in targeted exosomal delivery systems engineered by aptamer for future strategies to promote human health using this class of human-derived nanovesicles are summarized.