Allograft Inflammatory Factor-1 Gene Polymorphisms in Patients with Rheumatoid Arthritis
Allograft Inflammatory Factor-1 Gene Polymorphisms in Patients with Rheumatoid Arthritis
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DOI：
10.1089/gtmb.2011.0201
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发表时间：
2012-05-01
影响因子：
1.4
通讯作者：
Gawronska-Szklarz, Barbara
中科院分区：
文献类型：
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作者：
Pawlik, Andrzej;Kurzawski, Mateusz;Gawronska-Szklarz, Barbara
目的：同种异体移植炎性因子-1（AIF-1）是一种胞浆型炎症反应蛋白。在类风湿性关节炎（RA）患者的滑膜组织和流体中检测到AIF-1的表达增加。在AIF 1基因中已经发现了几种单核苷酸多态性，其中三种导致氨基酸序列的变化。本研究旨在探讨AIF 1基因rs 2259571：A>C、rs 2736182：G>A和rs 13195276：C>T多态性与RA的关系。我们检查了380例RA患者和376例对照组。结果如下：rs 2736182和rs 2259571基因型和等位基因在RA患者和对照组中的分布差异无统计学意义。此外，与疾病诊断年龄、类风湿因子、关节外表现和抗环瓜氨酸肽（CCP）抗体无显著相关性，而活动型RA与AA基因型患者相比，rs 2259571 CC基因型患者中疾病活动性评分（DAS 28）> 2.4的患者更容易被诊断（p = 0.007，比值比= 2.30，95%置信区间= 1.25-4.25）。结论：AIF 1 rs 2259571 CC基因型与RA活动型相关。
Aim: Allograft inflammatory factor-1 (AIF-1) is a cytoplasmic, inflammation-responsive protein. The increased expression of AIF-1 in synovial tissues and fluid from rheumatoid arthritis (RA) patients has been detected. Several single-nucleotide polymorphisms have been identified in the AIF1 gene, among them three leading to changes in amino acid sequence. The aim of this study was to examine the association between AIF1 rs2259571: A>C, rs2736182: G>A, and rs13195276: C>T polymorphisms and RA. We examined 380 patients with RA and 376 control subjects. Results: There were no statistically significant differences in distribution of rs2736182 and rs2259571 genotypes and alleles between RA patients and control group. Moreover, there were no significant associations with the age of disease diagnosis, rheumatoid factor, extra-articular manifestation, and anti-cyclic citrullinated peptide (CCP) antibodies, whereas the active form of RA (patients with disease activity score (DAS28) > 2.4) was more frequently diagnosed in patients with rs2259571 CC genotypes compared with patients with AA genotype (p = 0.007, odds ratio = 2.30, 95% confidence interval = 1.25-4.25). Conclusion: Our results suggest that the AIF1 rs2259571 CC genotype is associated with the active form of RA.