Arterial compliance and endothelial function.
Arterial compliance and endothelial function.
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DOI：
10.1007/s11892-007-0043-1
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发表时间：
2007-08-01
影响因子：
4.2
通讯作者：
Haynes, William G
中科院分区：
文献类型：
--
作者：
Correia, Marcelo L G;Haynes, William G
动脉顺应性降低（硬度增加）与心血管事件相关，可能是由于脉搏波反射更快导致心脏后负荷增加。内皮源性介质调节血管张力和结构，这两者都可以显着影响动脉僵硬度。因此，动脉硬度增加可能是内皮功能障碍易导致动脉粥样硬化并发症的机制。相反，内皮介质的治疗操作可以减少动脉僵硬度和心血管事件。已经开发了使用动脉硬度作为内皮扩张功能指标的技术;这些技术可以提供独特的预后信息，以识别高风险受试者。
Decreased arterial compliance (increased stiffness) correlates with cardiovascular events, possibly due to increased cardiac afterload caused by more rapidly reflected pulse waves. Endothelium-derived mediators regulate vascular tone and structure, both of which can markedly influence arterial stiffness. Thus, increased arterial stiffness may be a mechanism by which endothelial dysfunction predisposes to complications of atherosclerosis. Conversely, therapeutic manipulation of endothelial mediators could reduce arterial stiffness and cardiovascular events. Techniques have been developed that use measures of arterial stiffness as an index of endothelial dilator function; these may provide unique prognostic information to identify high-risk subjects.