Quantitative muscle ultrasonography in amyotrophic lateral sclerosis
Quantitative muscle ultrasonography in amyotrophic lateral sclerosis
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DOI：
10.1016/j.ultrasmedbio.2007.08.013
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发表时间：
2008-03-01
影响因子：
2.9
通讯作者：
Zwarts, Machiel J.
中科院分区：
文献类型：
--
作者：
Arts, Ilse M. P.;van Rooij, Frank G.;Zwarts, Machiel J.
在这项研究中，我们研究了定量肌肉超声检查是否可以检测早期肌萎缩侧索硬化症（ALS）的肌肉结构变化。对48例ALS患者行双侧胸锁乳突肌、肱二头肌/肱二头肌、前臂屈肌群、股四头肌和胫前肌5个肌群的横断扫描。25例患者还接受了肌束震颤筛查。定量分析显示所有肌肉的回声强度显著增加，两侧肱二头肌、前臂屈肌和股四头肌的肌肉厚度减少。除一名患者外，所有筛查患者的多块肌肉都容易检测到肌束震颤。我们的结论是，定量超声可用于检测肌肉变化所造成的ALS在早期阶段的疾病。
In this study, we examined whether quantitative muscle ultrasonography can detect structural muscle changes in early-stage amyotrophic lateral sclerosis (ALS). Bilateral transverse scans were made of five muscles or muscle groups (sternocleidomastoid, biceps brachii/brachialis, forearm flexor group, quadriceps femoris and anterior tibialis muscles) in 48 patients with ALS. Twenty-five patients were also screened for fasciculations. Quantitative analysis revealed a significant increase in echo intensity in all muscles and a decrease in muscle thickness of the biceps brachii, forearm flexors and quadriceps femoris on both sides. Fasciculations were easy to detect in multiple muscles of all screened patients except one. We conclude that quantitative ultrasonography can be used to detect muscle changes caused by ALS in an early phase of the disease.