HDL CHOLESTEROL PREDICTS CORONARY HEART-DISEASE MORTALITY IN OLDER PERSONS
HDL CHOLESTEROL PREDICTS CORONARY HEART-DISEASE MORTALITY IN OLDER PERSONS
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DOI：
10.1001/jama.274.7.539
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发表时间：
1995-08-16
影响因子：
120.7
通讯作者：
HAVLIK, RJ
中科院分区：
文献类型：
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作者：
CORTI, MC;GURALNIK, JM;HAVLIK, RJ
目标。研究总胆固醇和高密度脂蛋白胆固醇（HDL-C）与冠心病（CHD）死亡率和71岁及以上人群新发CHD事件发生率的关系。前瞻性队列研究，中位随访时间为4.4年。马萨诸塞州东波士顿、康涅狄格州纽黑文、爱荷华州爱荷华州和华盛顿县。共有2527名女性和1377名男性完成了访谈，进行了血脂测定，并存活了至少1年。新的冠心病事件在没有冠心病病史或住院的人中进行评估。CHD死亡（ICD-9编码410至414为潜在死因）;新发CHD事件（致死性CHD或CHD住院[ICD-9编码410至414]）。在校正了已确定的冠心病危险因素后，低HDL-C（
Objectives.-To examine the relationship of total cholesterol and high-density lipoprotein cholesterol (HDL-C) with coronary heart disease (CHD) mortality and with occurrence of new CHD events in persons aged 71 years and older.Design.-Prospective cohort study with a median of 4.4 years of follow-up.Setting.-East Boston, Mass; New Haven, Conn; and Iowa and Washington counties, Iowa.Participants.-A total of 2527 women and 1377 men who completed an interview, had serum lipid determinations, and survived at least 1 year. New CHD events were evaluated in persons with no CHD history or hospitalization.Main Outcome Measures.-Death due to CHD (ICD-9 codes 410 through 414 as underlying cause of death); new occurrence of CHD events (fatal CHD or hospitalization with CHD [ICD-9 codes 410 through 414]).Results.-After adjustment for established CHD risk factors, the relative risk (RR) of death due to CHD for those with low HDL-C (