Paracingulate sulcus morphology is associated with hallucinations in the human brain.
Paracingulate sulcus morphology is associated with hallucinations in the human brain.
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DOI：
10.1038/ncomms9956
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发表时间：
2015-11-17
影响因子：
16.6
通讯作者：
Simons JS
中科院分区：
文献类型：
--
作者：
Garrison JR;Fernyhough C;McCarthy-Jones S;Haggard M;Australian Schizophrenia Research Bank;Simons JS
幻觉在精神疾病中很常见，许多没有精神病的人也会经历幻觉。在这里，在153名参与者中，我们通过比较经历过幻觉的精神分裂症患者与没有经历幻觉的患者，在一些人口统计学和临床变量上匹配，研究了预测幻觉发生的大脑结构标记。使用新验证的视觉分类技术和自动化的数据驱动方法，幻觉与副扣带回沟（内侧前额叶皮层的一个褶皱）中特定的大脑形态差异相关，沟长度减少1厘米，幻觉的可能性增加19.9%，无论他们经历的感觉方式如何。研究结果表明，典型和非典型的人类经验的普遍特征的一个特定的形态学基础。 幻觉可以发生在健康人和精神疾病患者身上。Garrison等人在此报道了扣带旁沟（PCS）的特定脑形态差异可以决定精神分裂症患者幻觉的发生，而与感觉方式无关。
Hallucinations are common in psychiatric disorders, and are also experienced by many individuals who are not mentally ill. Here, in 153 participants, we investigate brain structural markers that predict the occurrence of hallucinations by comparing patients with schizophrenia who have experienced hallucinations against patients who have not, matched on a number of demographic and clinical variables. Using both newly validated visual classification techniques and automated, data-driven methods, hallucinations were associated with specific brain morphology differences in the paracingulate sulcus, a fold in the medial prefrontal cortex, with a 1 cm reduction in sulcal length increasing the likelihood of hallucinations by 19.9%, regardless of the sensory modality in which they were experienced. The findings suggest a specific morphological basis for a pervasive feature of typical and atypical human experience. Hallucinations can occur in both healthy individuals and patients with psychiatric disorders. Garrison et al. here report that specific brain morphology differences in the paracingulate sulcus (PCS) can determine the occurrence of hallucinations in schizophrenia, irrespective of sensory modality.