Chronic stress accelerates ultraviolet-induced cutaneous carcinogenesis
Chronic stress accelerates ultraviolet-induced cutaneous carcinogenesis
复制标题
DOI：
10.1016/j.jaad.2004.08.042
复制
发表时间：
2004-12-01
影响因子：
13.8
通讯作者：
Tausk, FA
中科院分区：
文献类型：
--
作者：
Parker, J;Klein, SL;Tausk, FA
Background: Physical and emotional stressors have been found to mediate a wide variety of biological changes including the facilitation of tumor progression; however most of these paradigms utilized artificial sources of neoplasms and stress.Methods: Skh mice were exposed to carcinogenic closes of ultraviolet light (UV). The stressed group was Subjected to the close proximity of fox urine Lis a source of stress from the presence of the odor of their natural predator, while the control group remained stress free.Results: A significant acceleration in the development of cutaneous neoplasms was observed in mice that had been exposed to the stressor. The first turner appeared in the group after 8 weeks, whereas nonstressed mice began to develop these by week 21.Conclusion: These results suggest that stress plays a role in potentiating Cutaneous carcinogenesis.
