EXOGENOUS HORMONES, REPRODUCTIVE HISTORY, AND COLON-CANCER (SEATTLE, WASHINGTON, USA)
EXOGENOUS HORMONES, REPRODUCTIVE HISTORY, AND COLON-CANCER (SEATTLE, WASHINGTON, USA)
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DOI：
10.1007/bf01804987
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发表时间：
1994-07-01
影响因子：
2.3
通讯作者：
WEISS, NS
中科院分区：
文献类型：
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作者：
JACOBS, EJ;WHITE, E;WEISS, NS
外源性激素、生殖史和结肠癌之间的关系在一项病例对照研究中调查了30-62岁的女性。该研究于1985年至1989年间在美国华盛顿州西雅图市区进行，包括193例结肠癌病例和194例对照。有1。结肠癌与口服避孕药的使用、胎次、第一胎年龄、子宫切除或卵巢切除状态、绝经年龄之间的总体关联不大。在40岁或40岁以后使用非避孕激素，最可能的是激素替代疗法（HRT），与结肠癌风险降低相关（调整优势比[or] = 0.60, 95%可信区间[CI] = 0.35-1.01），特别是在使用超过5年的女性中（or = 0.47, 95% CI = 0.24-0.91）。虽然先前的研究结果并不一致，但鉴于对其潜在风险和益处的持续争论，激素替代疗法对结肠癌的任何保护作用都是重要的。
The associations between exogenous hormones, reproductive history, and colon cancer were investigated in a case-control study among women aged 30-62 years. The study was conducted in the Seattle, Washington (USA) metropolitan area between 1985 and 1989 and included 193 incident cases of colon cancer and 194 controls. There was 1. little overall association between colon cancer and oral contraceptive use, parity, age at first birth, hysterectomy or oophorectomy status, or age at menopause. Use of noncontraceptive hormones at or after age 40, most likely hormone replacement therapy (HRT), was associated with decreased risk of colon cancer (adjusted odds ratio [OR] = 0.60, 95 percent confidence interval [CI] = 0.35-1.01), particularly among women with more than five years of use (OR = 0.47, 95 percent CI = 0.24-0.91). While results from previous studies have not been consistent, any protective effect of HRT against colon cancer would be important given the continuing debate over its potential risks and benefits.